The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery

This study has been completed.
Information provided by (Responsible Party):
Yonsei University Identifier:
First received: March 28, 2011
Last updated: February 2, 2012
Last verified: February 2012

This study was designed to investigate the effects of epidural anesthesia combined with general anesthesia during laparoscopic surgery. The investigators hypothesized that epidural anesthesia will effectively block the activation of the sympathetic nervous system during surgery, thus activating nitric oxide and reducing splanchnic ischemia and decrease in postoperative renal function.

Condition Intervention
Prostate Cancer
Procedure: Epidural anesthesia

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Bio-availability Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery

Resource links provided by NLM:

Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • blood pressure with heart rate variability [ Time Frame: 10 minutes after anesthesia induction ] [ Designated as safety issue: No ]

Enrollment: 45
Study Start Date: November 2010
Study Completion Date: October 2011
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: G group
G group = General anesthesia group
Experimental: G+E group
G+E group = General anesthesia + epidural anesthesia group
Procedure: Epidural anesthesia
0.5% ropivacaine infusion via epidural catheter at 5ml/hr during general anesthesia


Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • ASA class 1 or 2 adult patients scheduled for endoscopic prostatectomy

Exclusion Criteria:

  • Patient refusal
  • Patients on diuretics
  • Patients with renal failure (eGFR < 60 ml/min/1.73 m2)
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Please refer to this study by its identifier: NCT01325844

Korea, Republic of
Severance Hospital
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University
  More Information

No publications provided

Responsible Party: Yonsei University Identifier: NCT01325844     History of Changes
Other Study ID Numbers: 4-2010-0537
Study First Received: March 28, 2011
Last Updated: February 2, 2012
Health Authority: South Korea: Korea Food and Drug Administration (KFDA)

Additional relevant MeSH terms:
Central Nervous System Agents
Central Nervous System Depressants
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses processed this record on March 26, 2015