Changes of Functional Connectivity After rTMS in Depression
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|ClinicalTrials.gov Identifier: NCT01325831|
Recruitment Status : Completed
First Posted : March 30, 2011
Last Update Posted : February 2, 2012
|Condition or disease||Intervention/treatment||Phase|
|Major Depression||Device: repetitive transcranial magnetic stimulation(rTMS) Device: Sham repetitive transcranial magnetic stimulation(rTMS)||Phase 4|
Up to now, 24 patients with major depression and 6 normal controls are enrolled. Twenty-three patients and 4 normal participants have taken 10 days rTMS. One patients and one control withdrew their consent without any reason and one control withdrew the consent because of headache.
We scanned fMRIs(to examine functional connectivity)twice for each participant, which were taken 3 days before the first and 3 days after the last rTMS.
All of participants have not reported side effects except mild headahe. There's been no seizure event up to now.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||44 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Change of Dopamine Pathway After rTMS Treatment in Major Depressive Disorder|
|Study Start Date :||May 2009|
|Primary Completion Date :||June 2011|
|Study Completion Date :||June 2011|
|Experimental: transcranial magnetic stimluation||
Device: repetitive transcranial magnetic stimulation(rTMS)
10-day course of 10 Hz rTMS on left dorsolateral prefrontal cortex of the subjects.
Other Name: MAGSTIM
|Sham Comparator: rTMS_sham||
Device: Sham repetitive transcranial magnetic stimulation(rTMS)
Sham repetitive transcranial magnetic stimulation(rTMS)
- change of functional connectivity between pre/post rTMS [ Time Frame: 14 days ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01325831
|Korea, Republic of|
|Department of Psychiatry, Severance Hospital|
|Seoul,, Korea, Republic of, 120-752|
|Principal Investigator:||EUN LEE, M.D., Ph.D.||Yonsei University College of Medicine, Severance Hospital|