Aerobic Interval Training in Patients With Atrial Fibrillation
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|ClinicalTrials.gov Identifier: NCT01325675|
Recruitment Status : Completed
First Posted : March 30, 2011
Last Update Posted : January 8, 2016
|Condition or disease||Intervention/treatment||Phase|
|Atrial Fibrillation||Behavioral: Interval training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||51 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Aerobic Interval Training in Patients With Paroxysmal or Persistent Atrial Fibrillation|
|Study Start Date :||April 2011|
|Actual Primary Completion Date :||August 2013|
|Actual Study Completion Date :||February 2014|
Experimental: Interval training
Behavioral: Interval training
Aerobic interval training will be performed with 4 times of 4 minutes intervals at an intensity of 90-95% of maximum heart rate and active pauses of 3 minutes between intervals. 3 times a week for 12 weeks.
No Intervention: Control
Live as usual
- Change in burden of atrial fibrillation [ Time Frame: Baseline and 4 weeks after ended intervention period ]Burden of atrial fibrillation(number of episodes, duration(percent of the day)) continually measured, and reported by the patient. Analysed for the patients in total, with sub analysis in the groups of paroxysmal and persistent AF and in those with a low burden of atrial fibrillation vs. those with a larger burden.
- Size of left atrium and ventricle [ Time Frame: Baseline and after ended intervention period(12 weeks) ]Atrial and ventricular size will be evaluated by echocardiography and MRI.
- Blood samples [ Time Frame: Baseline and after ended intervention period(12 weeks) ]Interleukin-6, pro-BNP, d-dimer and von Willenbrands factor are measured.
- Endothelial function [ Time Frame: Baseline and after ended intervention period(12 weeks) ]FMD
- Atrial extrasystoles [ Time Frame: Baseline and after ended intervention period(12 weeks) ]Atrial extrasystoles on 48h Holter monitoring. Will alse be measured in the first week of training.
- Ablation procedure [ Time Frame: Measured during the ablation procedure (day 1) ]Duration of ablation, number of ablation points, success.
- Maximal oxygen uptake [ Time Frame: Baseline and after ended intervention period(12 weeks) ]
- Atrial and ventricular function [ Time Frame: Baseline and after ended intervention period(12 weeks) ]Atrial and ventricular function measured by MR and echocardiography
- Fibrosis [ Time Frame: Baseline and after ended intervention period(12 weeks) ]Fibrosis in left atrium and left ventricle measured by MRI.
- Quality of life [ Time Frame: Baseline and after ended intervention period(12 weeks) ]Measured with SF-36, Symptom and Severity Checklist and EHRA score of AF- related symptoms
- Burden of atrial fibrillation in the intervention period [ Time Frame: Week 1-4, 5-8 and 9-12 ]The intervention period is divided into 3 periods of 4 weeks each. The mean burden of atrial fibrillation(percent of time with atrial fibrillation) and number of episodes in each of those periods will be assessed to see if exercise changes the amount of fibrillation.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01325675
|Norwegian University of Science and Technology|
|Trondheim, Norway, 7491|
|Study Chair:||Jan Paal Loennechen, PhD||St. Olavs Hospital|
|Study Chair:||Ulrik Wisløff, PhD||Norwegian University of Science and Technology|