A Study to Compare the Efficacy and Safety of Tacrolimus Capsules in Patient With Myasthenia Gravis
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Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
A Randomized, Double-blinded, Placebo-controlled, and Multi-centered Clinical Trial Evaluating the Efficacy and Safety of Tacrolimus Capsule in Myasthenia Gravis That Was Insufficiently Treated by Glucocorticoid Therapy
Study Start Date :
Actual Primary Completion Date :
Actual Study Completion Date :
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Ages Eligible for Study:
18 Years to 70 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
diagnosed as myasthenia gravis (MG) by clinical diagnosis
QMG scores ≥7 at the time of enrollment
basic treatment drugs are mainly glucocorticoids, and the efficacy of glucocorticoid therapy was not sufficient
receiving blood purification therapy or immunoglobulin therapy within 8 weeks before the study
QMG swallowing function score ≥ 2 points or QMG vital capacity = 3
abnormal hepatic functions
uncontrolled diabetes patients
immuno-inhibitors are forbidden due to malignancy, history of malignancy or history of HIV infection
patients who are allergic to Tacrolimus or macrolide antibiotics