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Effects of Increased Muscle Mass on Resting Metabolic Rate

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ClinicalTrials.gov Identifier: NCT01325038
Recruitment Status : Completed
First Posted : March 29, 2011
Last Update Posted : March 29, 2011
Sponsor:
Information provided by:
University Hospital, Linkoeping

Brief Summary:

Healthy males are randomized to isometric exercise for three months with either extra protein or extra calories in the form of a fast food meal/day in order to study if increase in muscle mass increases resting metabolic rate and if this is affected by presumed increased caloric intake as compared with only proteins.

Body-composition was measured with Dual-Energy X-ray Absorbimetry (DEXA) and RMR was measured by registration of CO2 production and O2 consumption.


Condition or disease Intervention/treatment Phase
Healthy Subjects Procedure: Isometric exercise Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 24 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Study Start Date : January 2008
Actual Primary Completion Date : June 2008
Actual Study Completion Date : August 2009

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Active Comparator: extra protein supplement
isometric training with addition of extra protein
Procedure: Isometric exercise
Isometric exercise several times/week for three months

Active Comparator: extra food supplement
isometric exercise with addition of extra food and calories: one fast food meal/day
Procedure: Isometric exercise
Isometric exercise several times/week for three months




Primary Outcome Measures :
  1. change in resting metabolic rate [ Time Frame: 3 months ]
    measurement of resting metabolic rate at baseline and at the end of the three month trial period


Secondary Outcome Measures :
  1. change in muscle mass [ Time Frame: 3 months ]
    measurement of muscle mass with DEXA at baseline and at the end of the three month trial period



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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy males

Exclusion Criteria:

  • significant disease
  • inability to exercise

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01325038


Locations
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Sweden
University Hospital of Linkoping
Linkoping, Sweden, 58185
Sponsors and Collaborators
University Hospital, Linkoeping
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Fredrik H Nystrom MD PhD, Linköping University, Sweden
ClinicalTrials.gov Identifier: NCT01325038    
Other Study ID Numbers: Beach08
First Posted: March 29, 2011    Key Record Dates
Last Update Posted: March 29, 2011
Last Verified: March 2011
Keywords provided by University Hospital, Linkoeping:
resting metabolic rate