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Development of 3T Magnetic Resonance Research Methods for NIA Studies

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT01324206
Recruitment Status : Recruiting
First Posted : March 28, 2011
Last Update Posted : April 3, 2019
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) )

Brief Summary:


- Magnetic resonance imaging (MRI) studies provide important information on the structure and function of various body systems, including the brain, muscles, joints, heart, and blood vessels. Scientific applications of MRI scans often use techniques that need to be modified or refined before they are used in clinical studies. To develop and modify these techniques for the new Philips 3T Achieva whole-body MRI scanner, researchers are interested in conducting trial MRI scans on healthy individuals and individuals with conditions that require imaging studies.


- To conduct preliminary trials of the 3T MRI facility to develop and refine MRI scanning procedures.


- Individuals at least 18 years of age who are able to have magnetic resonance imaging.


  • Participants will be screened with a full medical history and physical examination, as well as blood and urine tests.
  • Participants will have an MRI scan using the 3T scanner. Some scans may require the use of a contrast agent or radiotracer, which is a small amount of radioactive substance that will be injected before the start of the scan. Some participants may be asked to perform tasks of thinking and movement while in the scanner, in order to test the procedures required for a functional MRI scan.
  • No treatment will be provided as part of this protocol.

Condition or disease
Normal Physiology

Detailed Description:
Magnetic resonance imaging (MRI) studies yield important information on the structure and function of various body systems including the brain, muscles, joints, heart, blood vessels and other body areas. Unlike clinical MRI imaging, scientific applications often utilize techniques that either requires de-novo development or modification of existing research or commercially available protocols before implementation in clinical studies. The proposed protocol is intended to allow MRI scanning on human subjects for the development and refinement of MRI scanning procedures before implementation in larger scale clinical National Institute on Aging (NIA) research studies. We will evaluate a variety of MRI pulse sequences on normal volunteers and individuals with a variety of medical conditions to determine optimal protocols for use in normal volunteers and patient populations. In addition, participants can be recruited and scanned to provide additional data for already approved NIA studies.

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Study Type : Observational
Estimated Enrollment : 500 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Development of 3T Magnetic Resonance Research Methods for NIA Studies
Actual Study Start Date : August 5, 2008

Healthy Volunteers
Healthy Volunteers 18 years or older

Primary Outcome Measures :
  1. Develop and refine scanning procedures [ Time Frame: 2 months ]
    To develop and refine specific imaging and spectroscopic methods.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy volunteers, male and female, 18yrs and older

Age 18 or older.

Control subjects or persons identified by an investigator to have a condition of interest for exploratory studies related to the patient s illness or other feature that is relevant to other or future NIA studies

Capable of providing informed consent


Any condition or non-removable device contraindicated for MRI, as assessed by the attached safety questionnaire.

Weight greater than the specified limit of the scanner bed


GFR < 60 ml/min/1.73m(2), if receiving IV contrast

Participants scheduled for an MRI with contrast will not be eligible for this MRI if the Investigator believes that their enrollment is not in their best medical interest.

Participants requested to complete an exercise protocol will not be eligible for an exercise MRI if they do not meet the eligibility criteria for that particular exercise protocol. Examples include joint replacements that may be affected by the defined exercise protocol or which may prevent MRI analysis or any condition, in the opinion of the investigator, that would prevent successful completion of the exercise protocol such as, but not limited to reported osteoarthritis, rheumatoid arthritis and/or fibromyalgia.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01324206

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Contact: Denise L Melvin, R.N. (410) 350-3924
Contact: Richard G Spencer, M.D. (410) 558-8226

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United States, Maryland
National Institute of Aging, Clinical Research Unit Recruiting
Baltimore, Maryland, United States, 21224
Contact: NIA Studies Recruitment    410-350-3941   
Sponsors and Collaborators
National Institute on Aging (NIA)
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Principal Investigator: Richard G Spencer, M.D. National Institute on Aging (NIA)

Additional Information:
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Responsible Party: National Institute on Aging (NIA) Identifier: NCT01324206     History of Changes
Other Study ID Numbers: 080238
First Posted: March 28, 2011    Key Record Dates
Last Update Posted: April 3, 2019
Last Verified: March 26, 2019

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) ):
Magnetic Resonance Imaging
Healthy Volunteers