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Trial record 1 of 1 for:    MRI #08-AG-0238
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Development of 3T Magnetic Resonance Research Methods for NIA Studies

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ClinicalTrials.gov Identifier: NCT01324206
Recruitment Status : Recruiting
First Posted : March 28, 2011
Last Update Posted : March 17, 2023
Sponsor:
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) )

Study Description
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Brief Summary:

Background:

- Magnetic resonance imaging (MRI) studies provide important information on the structure and function of various body systems, including the brain, muscles, joints, heart, and blood vessels. Scientific applications of MRI scans often use techniques that need to be modified or refined before they are used in clinical studies. To develop and modify these techniques for the new Philips 3T Achieva whole-body MRI scanner, researchers are interested in conducting trial MRI scans on healthy individuals and individuals with conditions that require imaging studies.

Objectives:

- To conduct preliminary trials of the 3T MRI facility to develop and refine MRI scanning procedures.

Eligibility:

- Individuals at least 18 years of age who are able to have magnetic resonance imaging.

Design:

  • Participants will be screened with a full medical history and physical examination, as well as blood and urine tests.
  • Participants will have an MRI scan using the 3T scanner. Some scans may require the use of a contrast agent or radiotracer, which is a small amount of radioactive substance that will be injected before the start of the scan. Some participants may be asked to perform tasks of thinking and movement while in the scanner, in order to test the procedures required for a functional MRI scan.
  • No treatment will be provided as part of this protocol.

Condition or disease
Normal Physiology

Detailed Description:
Magnetic resonance imaging (MRI) studies yield important information on the structure and function of various body systems including the brain, muscles, joints, heart, blood vessels and other body areas. Unlike clinical MRI imaging, scientific applications often utilize techniques that either requires de-novo development or modification of existing research or commercially available protocols before implementation in clinical studies. The proposed protocol is intended to allow MRI scanning on human subjects for the development and refinement of MRI scanning procedures before implementation in larger scale clinical National Institute on Aging (NIA) research studies. We will evaluate a variety of MRI pulse sequences on normal volunteers and individuals with a variety of medical conditions to determine optimal protocols for use in normal volunteers and patient populations. In addition, participants can be recruited and scanned to provide additional data for already approved NIA studies.
Study Design
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Study Type : Observational
Estimated Enrollment : 500 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Development of 3T Magnetic Resonance Research Methods for NIA Studies
Actual Study Start Date : November 3, 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: MRI Scans

Groups and Cohorts
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Group/Cohort
Healthy Volunteers
Healthy Volunteers, 18 or older years


Outcome Measures
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Primary Outcome Measures :
  1. Develop and refine scanning procedures [ Time Frame: 2 months ]
    To develop and refine specific imaging and spectroscopic methods.


Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy volunteers, male and female, 18yrs and older
Criteria
  • INCLUSION CRITERIA:

Age 18 or older.

Control subjects or persons identified by an investigator to have a condition of interest for exploratory studies related to the patient s illness or other feature that is relevant to other or future NIA studies

Capable of providing informed consent

EXCLUSION CRITERIA:

Any condition or non-removable device contraindicated for MRI, as assessed by the attached safety questionnaire.

Weight greater than the specified limit of the scanner bed

Pregnancy

Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01324206


Contacts
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Contact: Sarah Park, R.N. (410) 350-7315 sarah.park@nih.gov
Contact: Richard G Spencer, M.D. (410) 558-8226 spencerri@mail.nih.gov

Locations
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United States, Maryland
National Institute of Aging, Clinical Research Unit Recruiting
Baltimore, Maryland, United States, 21224
Contact: NIA Studies Recruitment    410-350-3941    niastudiesrecruitment@mail.nih.gov   
Sponsors and Collaborators
National Institute on Aging (NIA)
Investigators
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Principal Investigator: Richard G Spencer, M.D. National Institute on Aging (NIA)
More Information
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Additional Information:

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Responsible Party: National Institute on Aging (NIA)
ClinicalTrials.gov Identifier: NCT01324206    
Other Study ID Numbers: 080238
08-AG-0238
First Posted: March 28, 2011    Key Record Dates
Last Update Posted: March 17, 2023
Last Verified: February 2, 2023
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided
Plan Description: .There is ongoing discussion within the NIA IRP and a plan has not been finalized yet.

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) ):
Magnetic Resonance Imaging
Healthy Volunteers
Natural History