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Development of 3T Magnetic Resonance Research Methods for NIA Studies

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 26, 2017 by National Institutes of Health Clinical Center (CC)
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) ) Identifier:
First received: March 25, 2011
Last updated: March 11, 2017
Last verified: January 26, 2017


- Magnetic resonance imaging (MRI) studies provide important information on the structure and function of various body systems, including the brain, muscles, joints, heart, and blood vessels. Scientific applications of MRI scans often use techniques that need to be modified or refined before they are used in clinical studies. To develop and modify these techniques for the new Philips 3T Achieva whole-body MRI scanner, researchers are interested in conducting trial MRI scans on healthy individuals and individuals with conditions that require imaging studies.


- To conduct preliminary trials of the 3T MRI facility to develop and refine MRI scanning procedures.


- Individuals at least 18 years of age who are able to have magnetic resonance imaging.


  • Participants will be screened with a full medical history and physical examination, as well as blood and urine tests.
  • Participants will have an MRI scan using the 3T scanner. Some scans may require the use of a contrast agent or radiotracer, which is a small amount of radioactive substance that will be injected before the start of the scan. Some participants may be asked to perform tasks of thinking and movement while in the scanner, in order to test the procedures required for a functional MRI scan.
  • No treatment will be provided as part of this protocol.


Study Type: Observational
Official Title: Development of 3T Magnetic Resonance Research Methods for NIA Studies

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 500
Study Start Date: August 5, 2008
Detailed Description:
Magnetic resonance imaging (MRI) studies yield important information on the structure and function of various body systems including the brain, muscles, joints, heart, blood vessels and other body areas. Unlike clinical MRI imaging, scientific applications often utilize techniques that either requires de-novo development or modification of existing research or commercially available protocols before implementation in clinical studies. The proposed protocol is intended to allow MRI scanning on human subjects for the development and refinement of MRI scanning procedures before implementation in larger scale clinical National Institute on Aging (NIA) research studies. We will evaluate a variety of MRI pulse sequences on normal volunteers and individuals with a variety of medical conditions to determine optimal protocols for use in normal volunteers and patient populations. In addition, participants can be recruited and scanned to provide additional data for already approved NIA studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Age 18 or older.

Control subjects or persons identified by an investigator to have a condition of interest for exploratory studies related to the patient s illness or other feature that is relevant to other or future NIA studies

Capable of providing informed consent


Any condition or non-removable device contraindicated for MRI, as assessed by the attached safety questionnaire.

Weight greater than the specified limit of the scanner bed


GFR < 60 ml/min/1.73m(2), if receiving IV contrast

Participants scheduled for an MRI with contrast will not be eligible for this MRI if the Investigator believes that their enrollment is not in their best medical interest.

Participants requested to complete an exercise protocol will not be eligible for an exercise MRI if they do not meet the eligibility criteria for that particular exercise protocol. Examples include joint replacements that may be affected by the defined exercise protocol or which may prevent MRI analysis or any condition, in the opinion of the investigator, that would prevent successful completion of the exercise protocol such as, but not limited to reported osteoarthritis, rheumatoid arthritis and/or fibromyalgia.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01324206

Contact: Denise L Melvin, R.N. (410) 350-3924
Contact: Richard G Spencer, M.D. (410) 558-8226

United States, Maryland
National Institute of Aging, Clinical Research Unit Recruiting
Baltimore, Maryland, United States, 21224
Contact: NIA Studies Recruitment    410-350-3941   
Sponsors and Collaborators
National Institute on Aging (NIA)
Principal Investigator: Richard G Spencer, M.D. National Institute on Aging (NIA)
  More Information

Additional Information:
Responsible Party: National Institute on Aging (NIA) Identifier: NCT01324206     History of Changes
Other Study ID Numbers: 080238
Study First Received: March 25, 2011
Last Updated: March 11, 2017

Keywords provided by National Institutes of Health Clinical Center (CC):
Resonance processed this record on March 29, 2017