Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
China Medical University Hospital
ClinicalTrials.gov Identifier:
NCT01323894
First received: March 24, 2011
Last updated: June 15, 2016
Last verified: June 2016
  Purpose

The first year purpose:

The best concentration of canonical Wnt3a will be investigated in promoting the osteoblastogenesis of human mesenchymal stem cells.


Condition
Primary Disease

Study Type: Observational
Official Title: Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling/Hydroxyapatite Nanoparticles--Comparisons Between Non-viral and Viral Administration in Tissue Engineered Bone Regeneration

Further study details as provided by China Medical University Hospital:

Primary Outcome Measures:
  • Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling/Hydroxyapatite Nanoparticles--Comparisons between Non-viral and Viral administration in Tissue Engineered Bone Regeneration [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    August 2011-July 2013


Enrollment: 3
Study Start Date: August 2011
Study Completion Date: July 2013
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Detailed Description:

Our previous work is investigating the viral (Adv-BMP-2) administration for the development of a model to generate bones for possible use in clinical settings; the non-viral and viral administrations will be compared for best osteogenesis effects.

The first year purpose:

The best concentration of canonical Wnt3a will be investigated in promoting the osteoblastogenesis of human mesenchymal stem cells.

  Eligibility

Ages Eligible for Study:   10 Years to 80 Years   (Child, Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The patients require surgery ner iliac or abdomen areas
Criteria

Inclusion Criteria:

  • age above 10 years old
  • The patients require surgery ner iliac or abdomen areas

Exclusion Criteria:

  • age below 10 years old
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01323894

Locations
Taiwan
China Medical Universty Hospital
Taichung, Taiwan, 404
Sponsors and Collaborators
China Medical University Hospital
Investigators
Principal Investigator: Sopha Chia-Ning Chang, M.D. Ph.D. China Medical University Hospital
  More Information

Responsible Party: China Medical University Hospital
ClinicalTrials.gov Identifier: NCT01323894     History of Changes
Other Study ID Numbers: DMR-99-IRB-122 
Study First Received: March 24, 2011
Last Updated: June 15, 2016
Health Authority: Taiwan: Department of Health

ClinicalTrials.gov processed this record on July 21, 2016