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Endogenous Endophthalmitis in the Inpatient Setting

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01323868
First Posted: March 28, 2011
Last Update Posted: November 18, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Theodore Leng, Stanford University
  Purpose
The purpose of this study is to determine the rate of endogenous endophthalmitis in patients admitted to Stanford Hospital with a systemic infection and positive blood cultures, as this may improve the clinical care of this population of patients.

Condition
Endophthalmitis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Endogenous Endophthalmitis Rates, Clinical Course, and Outcomes

Further study details as provided by Theodore Leng, Stanford University:

Primary Outcome Measures:
  • Positive intraocular infection [ Time Frame: 1 day ]

Secondary Outcome Measures:
  • Visual acuity [ Time Frame: 2 wk ]

Enrollment: 145
Study Start Date: July 2010
Study Completion Date: June 2013
Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Detailed Description:

Some patients admitted to the hospital have blood-borne infections. Occasionally, these blood infections can end up inside the eye and cause an infection inside the eye (called endogenous endophthalmitis).

Prior to modern and rapid treatment of systemic infections, the rate of endogenous endophthalmitis was reported to be 37% in 1982. By 1997, the rate was reported to be 2.8%. This study aims to determine the rate of endogenous endophthalmitis at Stanford Hospital in the modern medical era in that our rates may be different as those reported in the literature. This potential difference may be a reflection of treatment protocols and antibiotics currently in use at Stanford Hospital.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Inpatients at Stanford Hospital with positive blood cultures who receive an Ophthalmology consultation and eye examination.
Criteria

Inclusion Criteria:All patients admitted to Stanford Hospital that have a systemic blood-borne infection and on which an Ophthalmology consult to rule out endogenous endophthalmitis is performed will be included in the study.

Exclusion Criteria:None

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01323868


Locations
United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Investigators
Principal Investigator: Theodore Leng Stanford University
  More Information

Responsible Party: Theodore Leng, Clinical Assistant Professor of Ophthalmology, Stanford University
ClinicalTrials.gov Identifier: NCT01323868     History of Changes
Other Study ID Numbers: SU-03232011-7621
IRB-18785
First Submitted: March 24, 2011
First Posted: March 28, 2011
Last Update Posted: November 18, 2014
Last Verified: November 2014

Additional relevant MeSH terms:
Endophthalmitis
Eye Infections
Infection
Eye Diseases