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Cognitive and Emotional Processing of Social Stimuli in Children and Youth With Autism Spectrum Disorder

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2012 by University of Tromso.
Recruitment status was:  Not yet recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01322984
First Posted: March 25, 2011
Last Update Posted: October 25, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
The Royal Norwegian Ministry of Health
Information provided by (Responsible Party):
University of Tromso
  Purpose
Children and youth diagnosed with autism spectrum disorder (ASD) have been shown to react abnormally to social stimuli, especially to human faces. Children and youth with ASD show less interest in social stimuli, and may even avoid looking at or interact with such stimuli. It has been proposed that social stimuli elicit reactions like fear and stress in individuals with ASD, and this explains the lack of interest and avoidance. The present project investigates this hypothesis.

Condition Intervention
Autism Spectrum Disorder Behavioral: Pictures Behavioral: Startle eliciting noise

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Cognitive and Emotional Processing of Social Stimuli in Children and Youth With Autism Spectrum Disorder

Resource links provided by NLM:


Further study details as provided by University of Tromso:

Primary Outcome Measures:
  • The eyeblink of the Startle reflex is measured. [ Time Frame: The startle reflex will be measured in relation to picture presentations during the experiment (e.g. day 1). ]
    The startle reflex is potentiated when participants are influenced by negative emotions. Accordingly, startle will be measured in relation to picture presentation to gauge the emotional effect of the pictures. It is expected that the ASD group will show fear potentiated startle to pictures of human faces.


Estimated Enrollment: 60
Study Start Date: March 2011
Estimated Primary Completion Date: January 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Normal controls
Normal children and youths
Behavioral: Pictures
The participants will be exposed to pictures of faces and non-facial stimuli presented on a PC screen.
Behavioral: Startle eliciting noise
Startle will be elicited by 95 dB noise, presented at different times after picture onset.
Experimental: ASD
Children and youths diagnosed with autism spectrum disorder (ASD)
Behavioral: Pictures
The participants will be exposed to pictures of faces and non-facial stimuli presented on a PC screen.
Behavioral: Startle eliciting noise
Startle will be elicited by 95 dB noise, presented at different times after picture onset.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   7 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

For ASD group:

Inclusion Criteria:

  • Diagnosed with autism spectrum disorders
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01322984


Locations
Norway
Department of Psychology, University of Tromso Not yet recruiting
Tromso, Troms, Norway, 9037
Contact: Ole Åsli, PhD    77646778    ole.asli@uit.no   
Principal Investigator: Ole Åsli, PhD         
Sponsors and Collaborators
University of Tromso
The Royal Norwegian Ministry of Health
  More Information

Additional Information:
Responsible Party: University of Tromso
ClinicalTrials.gov Identifier: NCT01322984     History of Changes
Other Study ID Numbers: 2010/238
First Submitted: March 2, 2011
First Posted: March 25, 2011
Last Update Posted: October 25, 2012
Last Verified: October 2012

Keywords provided by University of Tromso:
ASD
Startle

Additional relevant MeSH terms:
Disease
Autistic Disorder
Autism Spectrum Disorder
Child Development Disorders, Pervasive
Pathologic Processes
Neurodevelopmental Disorders
Mental Disorders