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Cognitive and Emotional Processing of Social Stimuli in Children and Youth With Autism Spectrum Disorder

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ClinicalTrials.gov Identifier: NCT01322984
Recruitment Status : Unknown
Verified October 2012 by University of Tromso.
Recruitment status was:  Not yet recruiting
First Posted : March 25, 2011
Last Update Posted : October 25, 2012
Sponsor:
Collaborator:
The Royal Norwegian Ministry of Health
Information provided by (Responsible Party):
University of Tromso

Brief Summary:
Children and youth diagnosed with autism spectrum disorder (ASD) have been shown to react abnormally to social stimuli, especially to human faces. Children and youth with ASD show less interest in social stimuli, and may even avoid looking at or interact with such stimuli. It has been proposed that social stimuli elicit reactions like fear and stress in individuals with ASD, and this explains the lack of interest and avoidance. The present project investigates this hypothesis.

Condition or disease Intervention/treatment Phase
Autism Spectrum Disorder Behavioral: Pictures Behavioral: Startle eliciting noise Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Cognitive and Emotional Processing of Social Stimuli in Children and Youth With Autism Spectrum Disorder
Study Start Date : March 2011
Estimated Primary Completion Date : January 2013

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Active Comparator: Normal controls
Normal children and youths
Behavioral: Pictures
The participants will be exposed to pictures of faces and non-facial stimuli presented on a PC screen.

Behavioral: Startle eliciting noise
Startle will be elicited by 95 dB noise, presented at different times after picture onset.

Experimental: ASD
Children and youths diagnosed with autism spectrum disorder (ASD)
Behavioral: Pictures
The participants will be exposed to pictures of faces and non-facial stimuli presented on a PC screen.

Behavioral: Startle eliciting noise
Startle will be elicited by 95 dB noise, presented at different times after picture onset.




Primary Outcome Measures :
  1. The eyeblink of the Startle reflex is measured. [ Time Frame: The startle reflex will be measured in relation to picture presentations during the experiment (e.g. day 1). ]
    The startle reflex is potentiated when participants are influenced by negative emotions. Accordingly, startle will be measured in relation to picture presentation to gauge the emotional effect of the pictures. It is expected that the ASD group will show fear potentiated startle to pictures of human faces.



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Ages Eligible for Study:   7 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

For ASD group:

Inclusion Criteria:

  • Diagnosed with autism spectrum disorders

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01322984


Locations
Norway
Department of Psychology, University of Tromso Not yet recruiting
Tromso, Troms, Norway, 9037
Contact: Ole Åsli, PhD    77646778    ole.asli@uit.no   
Principal Investigator: Ole Åsli, PhD         
Sponsors and Collaborators
University of Tromso
The Royal Norwegian Ministry of Health

Additional Information:
Responsible Party: University of Tromso
ClinicalTrials.gov Identifier: NCT01322984     History of Changes
Other Study ID Numbers: 2010/238
First Posted: March 25, 2011    Key Record Dates
Last Update Posted: October 25, 2012
Last Verified: October 2012

Keywords provided by University of Tromso:
ASD
Startle

Additional relevant MeSH terms:
Disease
Autistic Disorder
Autism Spectrum Disorder
Child Development Disorders, Pervasive
Pathologic Processes
Neurodevelopmental Disorders
Mental Disorders