Creating a Tissue Bank of Knee Capsules
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|ClinicalTrials.gov Identifier: NCT01320124|
Recruitment Status : Withdrawn
First Posted : March 22, 2011
Last Update Posted : April 23, 2015
|Condition or disease|
|Osteoarthritis Knee Joint Contractures|
We propose to constitute a bank of capsule samples from people with osteoarthritis undergoing primary total knee arthroplasty. It is expected that about 1.3% of people will develop a contracture post arthroplasty. A second sample will be taken from those that require surgery for release of contracture or revision. We will study histological characteristics and compare gene expression between the primary sample and the contracture sample in the same patient. In order to determine whether intrinsic genetic factors influence the develpment of joint contractures in the osteoarthritis population, all specimens will be analyzed for differential gene expression between patients with and without knee contractures post arthroplasty.
The remaining capsule tissue not used for this study will be banked and made available to other researchers.
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Official Title:||Knee Joint Contractures: Reversibility and Molecular Pathways|
|Study Start Date :||March 2011|
|Actual Primary Completion Date :||April 2015|
|Actual Study Completion Date :||April 2015|
osteoarthritis, total knee arthroplasty
The main cohort will have a total knee arthroplasty and will not develop a contracture post surgery. We will analyze differntial gene expression in all subjects.
contracture post arthroplasty
A small group (1.3%) will develop a contracture post total knee arthroplasty. A second sample will be taken at the time of corrective surgery. The 2 samples will be compared for gene expression in the same subject. This group will also be compared to the main cohort for differential gene expression.
- development of contracture post total knee arthroplasty [ Time Frame: Within 1 year ]1.3% of subjects are expected to develop a contracture post toal knee arthroplasty within a year of the surgery.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01320124
|The Ottawa Hospital|
|Ottawa, Ontario, Canada, K1H 8M2|
|Principal Investigator:||Guy Trudel, MD||University of Ottawa|