Subclinical Atherosclerosis Using Dual-source CT Coronary Angiography in Chinese Adults With Different Glycaemic Status
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|ClinicalTrials.gov Identifier: NCT01319201|
Recruitment Status : Unknown
Verified March 2011 by Shanghai Jiao Tong University School of Medicine.
Recruitment status was: Active, not recruiting
First Posted : March 21, 2011
Last Update Posted : March 21, 2011
Part I: Survey of Coronary Artery Calcification and Stenosis in Participants with Different Glycaemic Status
To evaluate coronary artery calcification and stenosis in community-dwelling adults with different glycaemic status, using dual-source CT angiography (CTA)
Study Subjects and Methods:
200 adults with normal glucose regulation (NGR), 200 with impaired glucose regulation (IGR) and 200 with type 2 diabetes were recruited from an urban community of Shanghai, who then underwent a comprehensive examination including questionnaire, anthropometric measurements, biochemical analysis and CTA.
Part II: Follow-up of Cardiovascular Events and Re-evaluation of Coronary Artery Calcification and Stenosis
Aims and Methods:
To investigate the development of cardiovascular diseases in subjects recruited in part I and re-evaluate coronary artery calcification and stenosis using CTA after 3-year follow-up
To identify the predictive value of coronary artery calcification and stenosis with future risks of cardiovascular diseases and the possible development of coronary artery disorders among participants with different glycaemic status
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||600 participants|
|Official Title:||Assessment of Subclinical Atherosclerosis Using Dual-source Computed Tomography Coronary Angiography in Chinese Adults With Different Glycaemic Status|
|Study Start Date :||April 2010|
Impaired glucose regulation
This group of subjects was diagnosed as impaired glucose regulation using oral glucose tolerance test.
Type 2 diabetes
This group of subjects was diagnosed as type 2 diabetes using oral glucose tolerance test.
Normal glucose regulation
This group of subjects was considered normal regarding glucose metabolism using oral glucose tolerance test.
- Number of participants who will develop cardiovascular events during follow-up [ Time Frame: 3 years ]Cardiovascular events include non-fatal myocardial infarction, non-fatal stroke and cardiovascular death. The progression of coronary artery calcium and stenosis is also evaluated at the final visit.
Biospecimen Retention: Samples With DNA
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01319201
|Shanghai Jiao-Tong University School of Medicine|
|Shanghai, China, 200025|
|Principal Investigator:||Guang Ning, M.D.; PH.D.||Shanghai Jiao Tong University School of Medicine|