Measurement of Kidney Blood Flow and Oxygen Levels by MRI
Comparison of renal blood flow measurements by PAH clearance and MRI
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||MRI for the Non-invasive Determination of Renal Blood Flow and Renal Oxygenation|
- Measurement of Renal Blood Flow of the Kidney by Both the PAH Method and by MRI [ Time Frame: Renal blood flow is estimated over 1 hour by PAH and 30 minutes by MRI (day 1) ] [ Designated as safety issue: No ]Renal blood flow is estimated by the PAH method.
- Measurement of Regional Blood Oxygenation by MRI [ Time Frame: One measure after furosemide (day 1) ] [ Designated as safety issue: No ]Estimate of renal blood flow by using MRI scans before and after the administration of furosemide
|Study Start Date:||October 2010|
|Study Completion Date:||June 2013|
|Primary Completion Date:||June 2012 (Final data collection date for primary outcome measure)|
Placebo Comparator: PAH
PAH measure of renal blood flow is first performed on subjects
Active Comparator: MRI after furosemide
After the PAH measurement is complete, subjects receive 20 mg furosemide and undergo BOLD MRI to estimate renal blood flow
Renal blood flow is measured after the administration of 20 mg of furosemide during MRI scan only.
Other Name: Lasix
The traditional measurement of renal blood flow in ml/min involves the collection of multiple blood and urine samples after an infusion of a drug called para-aminohippurate (PAH) is given. In this study, the investigators determine the ability of MRI to estimate renal blood flow. The primary hypothesis is that renal blood flow as measured by PAH clearance is similar to renal blood flow as estimated by MRI. The measurements by PAH clearance and MRI are both performed on the same day.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01318967
|United States, North Carolina|
|Wake Forest University Health Sciences|
|Winston-Salem, North Carolina, United States, 27157|
|Principal Investigator:||Michael Rocco, MD||Wake Forest School of Medicine|