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Angina in Non Coronary Artery Disease (HeartQuest)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01318629
Recruitment Status : Active, not recruiting
First Posted : March 18, 2011
Last Update Posted : April 17, 2013
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
Many patients undergoing coronary angiography are found to have no significant coronary artery disease (CAD) despite angina equivalent symptoms and/or electrocardiographic abnormalities suggestive of myocardial ischemia. The aim of this study is to systematically assess patients with angina equivalent symptoms despite normal coronary angiograms and to evaluate their symptoms according to a defined algorithm.

Condition or disease
Angina Pectoris Microvascular Angina Angina Pectoris, Variant

Detailed Description:
All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study. Patients are extensively examined during angiography using acetylcholine infusion and fast atrial pacing. According to the result of the additional invasive examination (vasospasm, vasoconstriction, vasodilation; symptoms during examination) a distinct diagnosis is attributed to the patients (small vessel disease, vasospastic disease, hypertensive heart disease, rhythm disorder, or extracardiac thoracic pain including pulmonary hypertension). Patients are followed-up after 10 years and prognosis of these patients is assessed (including mortality, cardiovascular events, re-angiography, functional status after 10 years).

Study Design

Study Type : Observational
Actual Enrollment : 718 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Invasive Findings in Patients With Angina Equivalent Symptoms But No Coronary Artery Disease; Results From the Heart Quest Cohort Study
Study Start Date : July 1996
Estimated Primary Completion Date : July 2018
Estimated Study Completion Date : July 2018

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Primary Outcome Measures :
  1. Cause of angina equivalent symptoms in patients with no coronary artery disease [ Time Frame: One day ]
  2. Prognosis of patients with angina equivalent symptoms and normal coronary arteries [ Time Frame: 10 years after baseline assessment ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study.
Criteria

Inclusion Criteria:

  • Coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008
  • No significant coronary stenoses (no coronary stenoses ≥ 50%)

Exclusion Criteria:

  • Severe valvular heart disease
  • Severe congestive heart failure
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01318629


Locations
Switzerland
Luzerner Kantonsspital
Luzern, Switzerland, 6000
Sponsors and Collaborators
Luzerner Kantonsspital
Investigators
Principal Investigator: Paul Erne, MD Luzerner Kantonsspital
More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Prof. Paul Erne, Luzerner Kantonsspital
ClinicalTrials.gov Identifier: NCT01318629     History of Changes
Other Study ID Numbers: Heart Quest
First Posted: March 18, 2011    Key Record Dates
Last Update Posted: April 17, 2013
Last Verified: April 2013

Additional relevant MeSH terms:
Angina Pectoris
Angina Pectoris, Variant
Chest Pain
Pain
Neurologic Manifestations
Nervous System Diseases
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Signs and Symptoms
Angina, Unstable