This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Effects of Xanthophylls on Optical Density

This study has been completed.
Information provided by (Responsible Party):
Volker Boehm, University of Jena Identifier:
First received: March 15, 2011
Last updated: July 26, 2012
Last verified: July 2012
The objective of the study was to investigate the influence of a intervention with lutein und zeaxanthin from crucifers on the optical density of the macular pigment of patients with non exudative age-related maculopathy. It is hypothesized that the applied study beverage elevates plasma concentrations of the administered xanthophylls and the optical density after 4 weeks of intervention.

Condition Intervention
Age-Related Macular Degeneration Dietary Supplement: Verum Dietary Supplement: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Alteration of Optical Density and Plasma Xanthophylls After Short Term Supplementation With Macular Carotenoids in Patients With AMD

Resource links provided by NLM:

Further study details as provided by Volker Boehm, University of Jena:

Primary Outcome Measures:
  • Optical density of macular pigment in AMD patients [ Time Frame: 10 weeks ]

Secondary Outcome Measures:
  • Concentration of xanthophylls in plasma of AMD patients [ Time Frame: 10 weeks ]
  • blood lipids [ Time Frame: 10 weeks ]

Enrollment: 20
Study Start Date: June 2010
Study Completion Date: July 2011
Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Lutein and zeaxanthin Dietary Supplement: Verum
10 subjects consume for 4 weeks a beverage containing 10 mg lutein and 3 mg zeaxanthin per day
Experimental: Placebo Dietary Supplement: Placebo
10 subjects consume for 4 weeks a placebo beverage without any lutein and zeaxanthin


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patients with non exudative age-related maculopathy

Exclusion Criteria:

  • intake of dietary supplements containing lutein and zeaxanthin
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01316198

Friedrich Schiller University
Jena, Thuringia, Germany, 07743
Sponsors and Collaborators
University of Jena
Principal Investigator: Volker Boehm, Dr. Friedrich Schiller University Jena, Institute of Nutrition, RG Bioactice Plant Products
  More Information

Responsible Party: Volker Boehm, Dr. Volker Böhm, University of Jena Identifier: NCT01316198     History of Changes
Other Study ID Numbers: BioPlant-LZ-AMD2011
Study First Received: March 15, 2011
Last Updated: July 26, 2012

Keywords provided by Volker Boehm, University of Jena:
human study
optical density

Additional relevant MeSH terms:
Macular Degeneration
Retinal Degeneration
Retinal Diseases
Eye Diseases processed this record on September 21, 2017