Dietary Antioxidants, Redox Tone and Health Promotion: an Orthomolecular Study of Interactions
Recruitment status was: Recruiting
Aging is associated with increased risk of various diseases, and much attention is given to the use of natural products (like herbs) and 'functional food', such as teas, for healthy aging.
The body is continuously exposed to potentially damaging agents (known as free radicals). The imbalance between the amount of free radicals and that of antioxidants in the body is known as oxidative stress. It is known that Type 2 DM is a state of increased oxidative stress, which is thought to lead to many long term complications of Type 2 DM, such as heart disease, vision problems and kidney failure. Antioxidant therapy, including increased consumption of antioxidant rich foods and beverages such as green tea, has been suggested as possibly beneficial in lowering the risk of these complications.
The purpose of this study is to examine the effects of regular intake of green tea on indices of oxidative stress and antioxidant defense within cells, plasma and urine so as to investigate if regular intake of green tea can be recommended for health promotion.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Basic Science
|Official Title:||Orthomolecular Mechanisms of Health Effects of Antioxidant Rich Diets, With Focus on Green Tea (Camellia Sinensis), DNA Protection and Key Biochemical Products/Effects of the Antioxidant Response Element|
- Activation of Antioxidant Response Element After Consumption of Green Tea [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]Biomarkers of antioxidant and oxidant balance, antioxidant response element activation (through gene and protein expression studies and plasma biomarkers) will be determined pre and post consumption of green tea
|Study Start Date:||February 2011|
|Estimated Study Completion Date:||April 2012|
|Estimated Primary Completion Date:||February 2012 (Final data collection date for primary outcome measure)|
Dietary Supplement: Green tea
Please refer to this study by its ClinicalTrials.gov identifier: NCT01315977
|China, Hong Kong|
|Our Lady of Maryknoll Hospital|
|Kowloon, Hong Kong, China|
|Study Chair:||Iris BENZIE, DPhil||The Hong Kong Polytechnic University|