We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Gait and Alzheimer Interaction Tracking (GAIT) Study (GAIT)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01315717
First Posted: March 15, 2011
Last Update Posted: September 22, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University Hospital, Angers
  Purpose
The purpose of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).

Condition
Gait Apraxia Alzheimer Disease Impaired Cognition Cerebral Atrophy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Maladie d'Alzheimer et Troubles Locomoteurs : Caracterisation Des Anomalies Temporelles de la Marche et Etude Des Correlats Anatomo-cognitifs

Resource links provided by NLM:


Further study details as provided by University Hospital, Angers:

Primary Outcome Measures:
  • Stride-to-stride variability of stride time [ Time Frame: baseline ]

Enrollment: 912
Study Start Date: November 2009
Study Completion Date: May 2016
Primary Completion Date: May 2016 (Final data collection date for primary outcome measure)
Groups/Cohorts
Group 1
Healthy subjects
Group 2
Patients with Mild Cognitive Impairment
Group 3
Patients with Mild AD
Group 4
Patients with Moderate AD

Detailed Description:

Although gait disorders are frequently associated with Alzheimer's disease (AD), few studies have focused on their characterization and mechanism. Exploring the associations of the gait characteristics - more particularly the gait variability - with the cognitive performance of AD patients on one hand, and with the morphological brain abnormalities on the other hand, could be useful to understanding the mechanisms of gait disorders in AD.

The main objective of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
All patients of the University Memory Center of Angers Hospital with respect to the eligibility criteria.
Criteria

Inclusion Criteria:

  • Age ≥ 60 years
  • Able to walk without walking aid on 15 metres
  • Score of Mini-Mental Examination (MMSE) > 10
  • Written informed consent to participate in the study (or trustworthy person)
  • Being affiliated to a social security regime
  • Near visual acuity ≥ 2/10
  • Absence of severe depression (score in the 15-item Geriatric Depression Scale ≤ 10)

Exclusion Criteria:

  • Score of Mini-Mental Examination (MMSE) ≤ 10
  • Subject suffering from pre-existing impellent disturbances
  • History of cerebrovascular accident or other cerebro-spinal pathology
  • Poor workmanship of the written or oral French language
  • Refusal of subject to be informed on possible hanging bare anomaly during study
  • Use of walking aid
  • Acute medical or surgical disease in the past 3 months
  • Refusal to participate (or trustworthy person)
  • Contra-indication to the achievement of a Magnetic Resonance Imaging
  • Near visual acuity < 2/10
  • Presence of severe depression (score in the 15-item Geriatric Depression Scale > 10)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01315717


Locations
France
Angers University Hospital
Angers, France, 49933
Sponsors and Collaborators
University Hospital, Angers
Investigators
Principal Investigator: Olivier Beauchet, MD, PhD Angers University Hospital
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: University Hospital, Angers
ClinicalTrials.gov Identifier: NCT01315717     History of Changes
Other Study ID Numbers: 2009-A00533-54
First Submitted: March 10, 2011
First Posted: March 15, 2011
Last Update Posted: September 22, 2016
Last Verified: March 2011

Additional relevant MeSH terms:
Atrophy
Brain Diseases
Alzheimer Disease
Apraxias
Cognitive Dysfunction
Gait Apraxia
Dementia
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Pathological Conditions, Anatomical
Psychomotor Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
Cognition Disorders
Gait Disorders, Neurologic