Gait and Alzheimer Interaction Tracking (GAIT) Study (GAIT)
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ClinicalTrials.gov Identifier: NCT01315717 |
Recruitment Status
:
Completed
First Posted
: March 15, 2011
Last Update Posted
: September 22, 2016
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Condition or disease |
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Gait Apraxia Alzheimer Disease Impaired Cognition Cerebral Atrophy |
Although gait disorders are frequently associated with Alzheimer's disease (AD), few studies have focused on their characterization and mechanism. Exploring the associations of the gait characteristics - more particularly the gait variability - with the cognitive performance of AD patients on one hand, and with the morphological brain abnormalities on the other hand, could be useful to understanding the mechanisms of gait disorders in AD.
The main objective of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).
Study Type : | Observational |
Actual Enrollment : | 912 participants |
Observational Model: | Cohort |
Time Perspective: | Cross-Sectional |
Official Title: | Maladie d'Alzheimer et Troubles Locomoteurs : Caracterisation Des Anomalies Temporelles de la Marche et Etude Des Correlats Anatomo-cognitifs |
Study Start Date : | November 2009 |
Actual Primary Completion Date : | May 2016 |
Actual Study Completion Date : | May 2016 |

Group/Cohort |
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Group 1
Healthy subjects
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Group 2
Patients with Mild Cognitive Impairment
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Group 3
Patients with Mild AD
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Group 4
Patients with Moderate AD
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- Stride-to-stride variability of stride time [ Time Frame: baseline ]

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Ages Eligible for Study: | 60 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- Age ≥ 60 years
- Able to walk without walking aid on 15 metres
- Score of Mini-Mental Examination (MMSE) > 10
- Written informed consent to participate in the study (or trustworthy person)
- Being affiliated to a social security regime
- Near visual acuity ≥ 2/10
- Absence of severe depression (score in the 15-item Geriatric Depression Scale ≤ 10)
Exclusion Criteria:
- Score of Mini-Mental Examination (MMSE) ≤ 10
- Subject suffering from pre-existing impellent disturbances
- History of cerebrovascular accident or other cerebro-spinal pathology
- Poor workmanship of the written or oral French language
- Refusal of subject to be informed on possible hanging bare anomaly during study
- Use of walking aid
- Acute medical or surgical disease in the past 3 months
- Refusal to participate (or trustworthy person)
- Contra-indication to the achievement of a Magnetic Resonance Imaging
- Near visual acuity < 2/10
- Presence of severe depression (score in the 15-item Geriatric Depression Scale > 10)

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01315717
France | |
Angers University Hospital | |
Angers, France, 49933 |
Principal Investigator: | Olivier Beauchet, MD, PhD | Angers University Hospital |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | University Hospital, Angers |
ClinicalTrials.gov Identifier: | NCT01315717 History of Changes |
Other Study ID Numbers: |
2009-A00533-54 |
First Posted: | March 15, 2011 Key Record Dates |
Last Update Posted: | September 22, 2016 |
Last Verified: | March 2011 |
Additional relevant MeSH terms:
Apraxias Gait Apraxia Alzheimer Disease Atrophy Cognitive Dysfunction Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases Tauopathies |
Neurodegenerative Diseases Neurocognitive Disorders Mental Disorders Pathological Conditions, Anatomical Psychomotor Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms Cognition Disorders Gait Disorders, Neurologic |