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Role of ST2 in Acute Pancreatitis

This study has been completed.
Information provided by:
Erasme University Hospital Identifier:
First received: March 11, 2011
Last updated: March 14, 2011
Last verified: September 2008
Acute pancreatitis is characterized by an inflammatory storm which regulatory pathways are not well known. The IL-1 cytokine family is activated early during acute pancreatitis and secretion of alarmins is speculated during pancreatic necrosis. IL-33 is a member of the IL-1 family, it can act as an alarmin and its receptor, ST2, is known to sequester MyD88 which might regulate the acute pancreatitis inflammatory storm. The aim of this study is to investigate ST2 pathway in human acute pancreatitis and in murine experimental models of acute pancreatitis.

Acute Pancreatitis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Study of ST2-IL-33 Pathway in Acute Pancreatitis

Resource links provided by NLM:

Further study details as provided by Erasme University Hospital:

Primary Outcome Measures:
  • Concentration of soluble ST2 in serum [ Time Frame: Within 30 days after onset of acute pancreatitis ]
    Concentration of soluble ST2 will be assessed in the serum of patient with an episode of acute pancreatitis, on the day of admission to the hospital as well as 24h, 48h, 7 days and 30 days later.

Enrollment: 44
Study Start Date: January 2005
Estimated Study Completion Date: September 2008
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Acute pancreatitis
Patients admitted in our institution for an episode of acute pancreatitis


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients of Erasme University Hospital

Inclusion Criteria:

  • Time to take blood sample less than 24h after the onset of symptoms of AP
  • Two of the following: typical pain, amylase and lipase concentrations more than 3x the upper normal limit, compatible modifications on imaging techniques

Exclusion Criteria:

  • Chronic pancreatitis
  Contacts and Locations
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Please refer to this study by its identifier: NCT01315613

Erasme Hospital
Brussels, Belgium, 1070
Sponsors and Collaborators
Erasme University Hospital
Principal Investigator: Romy Ouziel, MD Erasme Hospital
  More Information

Responsible Party: Romy Ouziel,, Erasme Hospital Identifier: NCT01315613     History of Changes
Other Study ID Numbers: RO-ST2
Study First Received: March 11, 2011
Last Updated: March 14, 2011

Additional relevant MeSH terms:
Pancreatic Diseases
Digestive System Diseases processed this record on September 21, 2017