Effect of a Medium Chain Triglyceride Supplemented Diet on Cognitive Function and Brain Activation in Type 1 Diabetes.
|ClinicalTrials.gov Identifier: NCT01315171|
Recruitment Status : Completed
First Posted : March 15, 2011
Last Update Posted : January 17, 2018
|Condition or disease||Intervention/treatment||Phase|
|Hypo-unawareness Type 1 Diabetes Mellitus||Dietary Supplement: Medium chain triglycerides||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effect of a Long-term Medium Chain Supplemented Diet on Cognitive Function and Brain Activation During Hypoglycemia in Type 1 Diabetes.|
|Study Start Date :||January 2012|
|Actual Primary Completion Date :||August 2015|
|Actual Study Completion Date :||October 2016|
Experimental: Medium chain supplemented diet
Subjects will have a diet during which all meals are supplemented with 4 tablespoons of medium chain triglyceride oil.
Dietary Supplement: Medium chain triglycerides
4 tablespoons/day for 2 weeks
No Intervention: Standard group
Subjects will continue with a standard western diabetes diet.
- Cognitive function tests [ Time Frame: 100 minutes ]Cognitive function will be assessed during hypoglycemia. 3 tests will be carried looking at working memory with number and word recollection.
- Brain activity [ Time Frame: 100 minutes ]The fMRI will be used to assess brain activity during hypoglycemia in the presence of medium chain triglycerides.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01315171
|United States, Connecticut|
|Yale University School of Medicine|
|New Haven, Connecticut, United States, 06511|
|Principal Investigator:||Robert Sherwin, MD||Yale University|