ClinicalTrials.gov
ClinicalTrials.gov Menu

Effects of Joint Effusion on Quadriceps Muscle

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01314820
Recruitment Status : Completed
First Posted : March 15, 2011
Last Update Posted : March 15, 2011
Sponsor:
Information provided by:
The Catholic University of Korea

Brief Summary:
The present study investigated whether the presence of fluid in the joint affected peak torque and the root mean square (RMS) values of surface electromyography (EMG) in patients symptomatic for osteoarthritis (OA).

Condition or disease Intervention/treatment Phase
Knee Osteoarthritis Other: normal saline injection Other: sham injection Not Applicable

Detailed Description:
Several studies have shown that knee effusion influenced quadriceps muscle activity and induced quadriceps arthrogenic muscle inhibition in normal volunteers. However, the effect of joint effusion on the quadriceps of patients with OA is controversial,and few patients with OA have been included in studies of joint effusion.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Joint Effusion on Quadriceps Muscle in Patients With Knee Osteoarthritis
Study Start Date : June 2009
Actual Primary Completion Date : January 2010
Actual Study Completion Date : June 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Osteoarthritis
U.S. FDA Resources

Arm Intervention/treatment
Active Comparator: normal saline injection
20 cc normal saline injection into the knee joint
Other: normal saline injection
20 cc normal saline injection into knee joint
Other Name: normal saline
Sham Comparator: sham injection
knee injection without saline
Other: sham injection
no saline injection
Other Name: no normal saline



Primary Outcome Measures :
  1. the peak torque of the knee extensors [ Time Frame: within 5 minutes after intervention ]
    to evaluate the effect of effusion on the peak torque of the knee extensors


Secondary Outcome Measures :
  1. the root mean square values of the vastus medialis and vastus lateralis muscles [ Time Frame: within 5 minutes after intervention ]
    to evaluate the effect of effusion on the RMS of the vastus medialis (VM) and vastus lateralis (VL) muscles



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   50 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • 50 years old or older with knee osteoarthritis
  • knee pain without joint effusion confirmed by ultrasonography

Exclusion Criteria:

  • the presence of knee joint effusion determined using US
  • a history of knee injury or surgery
  • a history of knee injection within 3 months
  • a history of inflammatory arthritis
  • taking anticoagulants
  • balance or gait disturbance
  • diabetes mellitus

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01314820


Locations
Korea, Republic of
Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea
Seoul, Korea, Republic of, 137-701
Sponsors and Collaborators
The Catholic University of Korea
Investigators
Study Director: Jongin Lee, M.D Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea

Publications:
Responsible Party: Department of Rehabilitation Medicine, Seoul St. Mary's Hospital,, College of Medicine, The Catholic University of Korea
ClinicalTrials.gov Identifier: NCT01314820     History of Changes
Other Study ID Numbers: KC09OISI0161
First Posted: March 15, 2011    Key Record Dates
Last Update Posted: March 15, 2011
Last Verified: January 2010

Keywords provided by The Catholic University of Korea:
Knee
Osteoarthritis
Effusion.

Additional relevant MeSH terms:
Osteoarthritis
Osteoarthritis, Knee
Hydrarthrosis
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases