Collection of Cerebrospinal Fluid and Tumor Tissue in Subjects With Metastatic Melanoma and Controls
|ClinicalTrials.gov Identifier: NCT01312506|
Recruitment Status : Withdrawn (Trial experienced funding issues, was never opened to accrual.)
First Posted : March 10, 2011
Last Update Posted : July 27, 2016
This study has two ultimate goals:
- Understand how the original melanoma from the skin spreads to the CNS. In order to study this we need to collect (and compare) the original skin melanoma, the CNS melanoma, as well as any other melanoma that has not metastasized to the CNS.
- Develop a diagnostic blood test that will early identify subjects at high risk for developing CNS metastasis or patients who may already have CNS metastasis but the MRI or the CAT scan cannot yet detect it. Thus, the investigators plan to collect CSF from subjects like you who have melanoma CNS metastases in order to confirm the presence of this biomarker.
|Condition or disease|
|Metastatic Melanoma CNS Metastases|
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Observational Model:||Case Control|
|Official Title:||Procurement of Central Nervous System and Extracranial Tumor Tissues, Cerebrospinal Fluid, and Serum/Plasma From Patients With Metastatic Melanoma to the CNS and Respective Controls for Gene Expression and Proteomic Profiling|
|Study Start Date :||July 2012|
|Actual Primary Completion Date :||July 2012|
|Actual Study Completion Date :||November 2012|
Subjects undergoing a craniotomy
This group will include those subjects who have consented to have either a craniotomy or a laminectomy to resect an intramedullary tumor.
Metastases, no craniotomy
These subjects have metastases but have either chosen not to undergo removal of the cancer or their neurosurgeon does not recommend surgical approach or they have been diagnosed with metastatic melanoma but do not have CNS metastases.
Subjects who do not have known melanoma or metastases.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01312506
|Principal Investigator:||Stergios Moschos, MD||University of Pittsburgh|