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Children's Susceptibility to Enterovirus 71 in Different Areas of Taiwan (DMR100-IRB-010)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2011 by China Medical University Hospital.
Recruitment status was:  Enrolling by invitation
Information provided by:
China Medical University Hospital Identifier:
First received: March 8, 2011
Last updated: NA
Last verified: March 2011
History: No changes posted
EV71 has caused large epidemics with lots of fatal cases and cases with sequelae. However, the clinical syndromes and severity of the same EV71 strain are very diverse, ranging from asymptomatic (71%) to fatal (0.05%) disease, and the pathogenesis remains unknown. In addition, the severe or fatal case incidence varies significantly differently in different areas of Taiwan. Although some viral virulence studies were performed, no clear viral virulence factor has been found. Therefore, host factors may be important to the clinical outcomes of EV71 infections. In addition, there were significantly different incidences of severe or fatal cases in different areas of Taiwan, for example, significantly more fatal or severe cases occurred in the central or southern Taiwan in comparison with in northern Taiwan. Whether this is related to host factors, social, behavioral or environmental factors remains unanswered. To find the most important factors associated with EV71 susceptibility, a thorough study involving genetics, social, behavioral or environmental factors among different areas of Taiwan is warranted and the findings will provide future prevention of EV71 and give help on early precaution and treatment of EV71.

Enterovirus 71, Host Genetics, Social, Behavior, Environmental Factors

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Specific Aims Are to Find Factors Associated With Different Severe/Fatal Incidences in Different Areas of Taiwan. We Will do 1. Comparison of Gene Variants in EV71 Cases With Different Severity and Normal Children in Different Areas of Taiwan to Find Susceptible Genes and Genetic Polymorphism Related to the Clinical Outcomes 2. Social, Behavioral and Environmental Factors Related to EV71 Infections in Different Areas of Taiwan

Further study details as provided by China Medical University Hospital:

Biospecimen Retention:   Samples With DNA

Estimated Enrollment: 200
Study Start Date: February 2011
Detailed Description:

The specific aims are to find factors associated with different severe/fatal incidences in different areas of Taiwan. We will do

  1. Comparison of gene variants in EV71 cases with different severity and normal children in different areas of Taiwan to find susceptible genes and genetic polymorphism related to the clinical outcomes
  2. Social, behavioral and environmental factors related to EV71 infections in different areas of Taiwan

Ages Eligible for Study:   up to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Symptoms very like Enterovirus type 71 of hand, foot, and mouth disease or Herpangina,

Inclusion Criteria:

- Enterovirus type 71

Exclusion Criteria:

- not Enterovirus type 71

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

Responsible Party: Kao-Pin,Hwang/Director of Pediatric Infectious Diseases, China Medical University Hospital Identifier: NCT01311921     History of Changes
Other Study ID Numbers: ChinaMUH
Study First Received: March 8, 2011
Last Updated: March 8, 2011

Keywords provided by China Medical University Hospital:
enterovirus 71, host genetics, social, behavior, environmental factors

Additional relevant MeSH terms:
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Virus Diseases processed this record on August 23, 2017