Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01311544
Recruitment Status : Completed
First Posted : March 9, 2011
Last Update Posted : May 16, 2012
Information provided by (Responsible Party):
Rennes University Hospital

Brief Summary:
The Magnetic Resonance angiography (MRA) of supraaortic vessels is essential for the etiologic of stroke. However, the techniques usually used provide only static evaluation (degree of stenosis, occlusion) but not dynamic. An ultra-fast 3D MRA originally developed for the cardiac imaging, k-t blast (Broad-use Linear Acquisition Speed-up Technique) could be used to review the supraaortic vessels. This MRA offers the following advantages: short acquisition time, wide spatial coverage (of the thoracic aorta to the distal encephalic arteries), 3D spatial resolution and high temporal resolution. These qualities are even more optimal with a high magnetic field (3T). The high temporal resolution is interesting because it provides to repeat a volume every eight seconds and thus to have a dynamic evaluation of vascular filling and to assess the vascular supply of the infarcted territory. This sequence is classified as a 4D MRA.

Condition or disease
Stroke, Acute

Study Type : Observational
Actual Enrollment : 92 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients
Study Start Date : March 2011

Primary Outcome Measures :
  1. Images quality for each cervical and intracranial arteries [ Time Frame: 6 months ]

Secondary Outcome Measures :
  1. Quantification of carotid stenosis with NASCET classification [ Time Frame: 6 months ]
  2. Study of dynamic vascular consequences of carotid stenosis [ Time Frame: 6 months ]

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with acute ischemic stroke

Inclusion Criteria:

  • Men and women over 18 years
  • Eligibility for intravenous thrombolytic treatment (National Institute of Neurological Disorders and Stroke criteria)
  • Permanent ischemic stroke confirm with encephalic MRI (Magnetic Resonance Imaging)
  • Patient able of accepting protocol information
  • Patient who received information about the protocol and had not expressed its opposition to participate

Exclusion Criteria:

  • Pacemaker
  • Surgical ferromagnetic clips
  • Cochlear implants
  • Intraocular metallic foreign body
  • Iron implants or objects likely to concentrate the Radio Frequency field
  • Claustrophobia
  • Known intolerance to contrast media (DOTAREM)
  • Pregnant women (Beta Human Chorionic gonadotrophin performed for biological assessment of thrombolysis)
  • Patient with severe kidney with Glomerular Filtration rate < 30 ml/min
  • Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01311544

Rennes University Hospital
Rennes, Brittany, France, 35033
Sponsors and Collaborators
Rennes University Hospital
Principal Investigator: jean-yves gauvrit Rennes University Hospital

Responsible Party: Rennes University Hospital Identifier: NCT01311544     History of Changes
Other Study ID Numbers: 2010-A01158-31
First Posted: March 9, 2011    Key Record Dates
Last Update Posted: May 16, 2012
Last Verified: May 2012

Additional relevant MeSH terms:
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases