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Effect of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery

This study has been completed.
Information provided by (Responsible Party):
Jin-Tae Kim, Seoul National University Hospital Identifier:
First received: September 20, 2009
Last updated: April 30, 2012
Last verified: March 2011
This study is conducted in order to evaluate the effect of remote ischemic preconditioning on children undergoing cardiac surgery, especially focusing on possible differences according to preoperative cyanosis.

Condition Intervention
Other: RIPC (remote ischemic preconditioning)

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Effect of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery: Implication of Preoperative Cyanosis

Resource links provided by NLM:

Further study details as provided by Seoul National University Hospital:

Primary Outcome Measures:
  • troponin level [ Time Frame: within the 1 day after operation ]
    troponin level will be checked 1, 6, 12 and 24 hours after operation. Ater making a graph (troponin-time), area under the curve will bw calculated.

Enrollment: 60
Study Start Date: October 2009
Study Completion Date: December 2011
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: remote ischemic preconditioning Other: RIPC (remote ischemic preconditioning)
RIPC will be performed by four 5-min cycles of lower limb ischemia and 5 in reperfusion using blood-pressure cuff inflated to a pressure 15 mmHg greater than the systolic arterial pressure measured via arterial line.


Ages Eligible for Study:   1 Month to 10 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • open heart surgery under cardiopulmonary bypass: ventricular septal defect, tetralogy of Fallot

Exclusion Criteria:

  • chromosomal defect
  • airway and parenchymal lung disease blood disorder
  • isolated atrail septal defect
  • immunodeficiency
  Contacts and Locations
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Please refer to this study by its identifier: NCT01311310

Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of, 110-744
Seoul national university hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Seoul National University Hospital
  More Information

Responsible Party: Jin-Tae Kim, assistant professor, Seoul National University Hospital Identifier: NCT01311310     History of Changes
Other Study ID Numbers: H-0907-028-286
Study First Received: September 20, 2009
Last Updated: April 30, 2012

Keywords provided by Seoul National University Hospital:
troponin, open heart surgery, children

Additional relevant MeSH terms:
Signs and Symptoms processed this record on May 23, 2017