Low Intensity Resistance Training With Partial Blood Flow Restriction for Quadriceps Strengthening (PBFR)
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|ClinicalTrials.gov Identifier: NCT01311206|
Recruitment Status : Completed
First Posted : March 9, 2011
Last Update Posted : June 28, 2011
|Condition or disease||Intervention/treatment||Phase|
|Knee Osteoarthritis Symptomatic Knee Osteoarthritis||Other: partial blood flow restriction Other: Low intensity exercise without partial blood flow restriction||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||50 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Outcomes Assessor)|
|Official Title:||Determining Efficacy of a Tolerable Means of Strengthening for Older Adults With Knee Osteoarthritis: Partial Blood Flow Restriction Low Intensity Resistance Training|
|Study Start Date :||February 2011|
|Actual Primary Completion Date :||June 2011|
|Actual Study Completion Date :||June 2011|
Partial Blood Flow Restriction (PBFR) during Low-Intensity Exercise.
Other: partial blood flow restriction
Partial Blood Flow Restriction (PBFR) Low-Intensity Exercise: using the Biodex 3 Dynamometer in isotonic mode at 10% (first 3 weeks), 15% (following 3 weeks) and 20% (final 3 weeks) of their 1RM for each side, while receiving PBFR in each exercising limb. The padded belts (65 mm in width and 650 mm in length) of the Kaatsu Master™ PBFR device (Sato Sports Plaza, Tokyo, Japan) will be applied to the proximal thigh as near to the hip joint as is comfortable. Before training each leg, subjects will be seated in a chair where an initial belt pressure of 37-40 mmHg will be applied. The belt then will be iteratively pressurized for 30 seconds and then relaxed for 10 seconds in increments of 20 mmHg from 100 mmHg to the final pressure of 160 mmHg. During exercise, the cuff pressure will be continuously controlled and monitored by the PBFR apparatus
Active Comparator: PBFR control
Low-Intensity Exercise without partial blood flow restriction.
Other: Low intensity exercise without partial blood flow restriction
Low-Intensity Exercise: using the Biodex 3 Dynamometer in isotonic mode at 10% (first 3 weeks), 15% (following 3 weeks) and 20% (final 3 weeks) of their 1RM for each side in each exercising limb without partial blood flow restriction.
- Change in isokinetic knee extensor strength after 9-week intervention [ Time Frame: Outcome will be measured at week 0 (baseline) and approximately 10 weeks later (after completion of 9-week intervention) ]This outcome will measure efficacy of 9-week intervention.
- Change in quadriceps volume assessed by MRI after completion of 9-week intervention [ Time Frame: outcome will be measured at week 0 and at approximately week 10 (after completion of 9-week intervention) ]This outcome will measure efficacy of the 9-week intervention.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01311206
|United States, Iowa|
|University of Iowa|
|Iowa City, Iowa, United States, 52242|