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The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2011 by China Medical University Hospital.
Recruitment status was:  Recruiting
Information provided by:
China Medical University Hospital Identifier:
First received: March 6, 2011
Last updated: March 8, 2011
Last verified: March 2011
Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system. However, it remains unclear for involvement of RAS in the pathogenesis of non-familial sick sinus syndrome. The researchers thus investigated the possible relationship between non-familial sick sinus syndrome and the polymorphism and haplotype of the AGT promoter.

Condition Intervention
Sick Sinus Syndrome Other: observation

Study Type: Observational
Study Design: Observational Model: Case Control

Resource links provided by NLM:

Further study details as provided by China Medical University Hospital:

Estimated Enrollment: 400
Study Start Date: February 2011
Groups/Cohorts Assigned Interventions
sick sinus syndrome Other: observation


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The case group includes 200 patients and the control group includes 200 patients.

Inclusion Criteria:

  • sick sinus syndrome

Exclusion Criteria:

  • 1.Severe systemic disease.
  • 2.Acute coronary syndrome.
  • 3.bradycardia with reversible cause.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01310920

Contact: Jan-Yow Chen, MD +886-4-22062121 ext 2311

China Medical University Hospital Recruiting
Taiwan, Taiwan, 404
Contact: Jan-Yow Chen, M.D.    +886-4-22062121 ext 2311   
Principal Investigator: Jan-Yow Chen, MD         
Sponsors and Collaborators
China Medical University Hospital
Principal Investigator: Jan-Yow Chen, M.D. China Medical University Hospital
  More Information

Responsible Party: Jan-Yow Chen, China Medical University hospital Identifier: NCT01310920     History of Changes
Other Study ID Numbers: DMR99-IRB-316
Study First Received: March 6, 2011
Last Updated: March 8, 2011

Additional relevant MeSH terms:
Sick Sinus Syndrome
Pathologic Processes
Arrhythmia, Sinus
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Heart Block processed this record on September 21, 2017