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Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia

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ClinicalTrials.gov Identifier: NCT01310907
Recruitment Status : Unknown
Verified March 2011 by China Medical University Hospital.
Recruitment status was:  Recruiting
First Posted : March 9, 2011
Last Update Posted : March 9, 2011
Sponsor:
Collaborator:
China Medical University, China
Information provided by:
China Medical University Hospital

Brief Summary:

Bradyarrhythmia, including sinus node dysfunction and atrioventricular block, is a major cause necessitating pacemaker implantation. In contrast to familial bradyarrhythmia known as by mutations at particular ion channels, limited information is available for the mechanistic study in non-familial bradyarrhythmia.

Possible gene polymorphisms related to non-familial bradyarrhythmia were studied. Comparison of multi-locus analysis and single-locus analysis will be analyzed between the cases and controls. Functional studies will perform to clarify the results of association study.


Condition or disease
Bradyarrhythmia

Study Type : Observational
Estimated Enrollment : 400 participants
Study Start Date : February 2011

Group/Cohort
sinus node dysfunction
Atrioventricular block
control




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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The case group include 200 patients and the control group include 200 patients.
Criteria

Inclusion Criteria:

  • The patients with non-familial bradyarrhythmia

Exclusion Criteria:

  • Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01310907


Contacts
Contact: Jan-Yow Chen, MD +422052121 ext 2311 janyow@ms77.hinet.net

Locations
Taiwan
China Medical University Hospital Recruiting
Taichung, Taiwan, 404
Contact: Jan-Yow Chen, MD    +88622052121 ext 2311    janyow@ms77.hinet.net   
Principal Investigator: Jan-Yow Chen, MD         
China Medical University Hospital Recruiting
Taichung, Taiwan, 404
Contact: Jan-Yow Chen, MD    +886-4-22052121 ext 2311    janyow@ms77.hinet.net   
Principal Investigator: Jan-Yow Chen, MD         
Sponsors and Collaborators
China Medical University Hospital
China Medical University, China
Investigators
Principal Investigator: Jan-Yow Chen, MD China Medical University Hospital

Additional Information:
Publications:
Responsible Party: Jan-Yow Chen M.D., China Medical University Hospital
ClinicalTrials.gov Identifier: NCT01310907     History of Changes
Other Study ID Numbers: DMR99-IRB-315
First Posted: March 9, 2011    Key Record Dates
Last Update Posted: March 9, 2011
Last Verified: March 2011

Additional relevant MeSH terms:
Bradycardia
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes