Try our beta test site

Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2011 by China Medical University Hospital.
Recruitment status was:  Recruiting
China Medical University, China
Information provided by:
China Medical University Hospital Identifier:
First received: March 6, 2011
Last updated: NA
Last verified: March 2011
History: No changes posted

Bradyarrhythmia, including sinus node dysfunction and atrioventricular block, is a major cause necessitating pacemaker implantation. In contrast to familial bradyarrhythmia known as by mutations at particular ion channels, limited information is available for the mechanistic study in non-familial bradyarrhythmia.

Possible gene polymorphisms related to non-familial bradyarrhythmia were studied. Comparison of multi-locus analysis and single-locus analysis will be analyzed between the cases and controls. Functional studies will perform to clarify the results of association study.


Study Type: Observational

Further study details as provided by China Medical University Hospital:

Estimated Enrollment: 400
Study Start Date: February 2011
sinus node dysfunction
Atrioventricular block


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The case group include 200 patients and the control group include 200 patients.

Inclusion Criteria:

  • The patients with non-familial bradyarrhythmia

Exclusion Criteria:

  • Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01310907

China Medical University Hospital
Taichung, Taiwan, 404
Sponsors and Collaborators
China Medical University Hospital
China Medical University, China
Principal Investigator: Jan-Yow Chen, MD China Medical University Hospital
  More Information

Additional Information:
Responsible Party: Jan-Yow Chen M.D., China Medical University Hospital Identifier: NCT01310907     History of Changes
Other Study ID Numbers: DMR99-IRB-315 
Study First Received: March 6, 2011
Last Updated: March 6, 2011

Additional relevant MeSH terms:
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes processed this record on February 17, 2017