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Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery (TRIMRIPC)

This study has been completed.
St. Olavs Hospital
Information provided by (Responsible Party):
Norwegian University of Science and Technology Identifier:
First received: February 2, 2011
Last updated: August 19, 2015
Last verified: August 2015
The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

Condition Intervention
Myocardial Injury
Behavioral: Exercise training
Procedure: remote ischemic preconditioning

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Basic Science
Official Title: Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Mitochondrial respiration [ Time Frame: 1 hour ]
    Oxygraph (Strathkelvin)

Enrollment: 60
Study Start Date: January 2011
Study Completion Date: July 2013
Primary Completion Date: May 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: ExerciseTr Behavioral: Exercise training
exercise training
Experimental: Remote ischemic preconditioning group Procedure: remote ischemic preconditioning
remote ischemic preconditioning
No Intervention: Control patient group


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients undergoing coronary heart surgery and heart transplantation

Exclusion Criteria:

  • myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)
  Contacts and Locations
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Please refer to this study by its identifier: NCT01308138

Norwegian University of Science and Technology, Medical Faculty
Trondheim, Sør-Trondelag, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
St. Olavs Hospital
Principal Investigator: Katrine Hordnes, MD NTNU
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Norwegian University of Science and Technology Identifier: NCT01308138     History of Changes
Other Study ID Numbers: TRIMRIPC
Study First Received: February 2, 2011
Last Updated: August 19, 2015

Keywords provided by Norwegian University of Science and Technology:
Physical Activity
Physical Deconditioning processed this record on May 24, 2017