Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Resection
The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary resection.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Prevention
|Official Title:||Effect of Remote Ischemic Preconditioning on Lung Injury in Patients Undergoing Pulmonary Resection:a Randomised Controlled Trial|
- Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing pulmonary lobectomy [ Time Frame: June,2013 ] [ Designated as safety issue: Yes ]PaO2/FiO2 in the limb RIPC group was significantly higher than that in the control group at 30 and 60 min after OLV, 30 min and 6 h after operation (all P<0.05)
- Cs and Cd [ Time Frame: June,2013 ] [ Designated as safety issue: Yes ]Cs and Cd in limb RIPC group were significantly higher than those in the control group at 30 and 60 min after OLV (all P<0.05)
- IL-6 and TNF-α [ Time Frame: June,2013 ] [ Designated as safety issue: Yes ]The IL-6 levels in the limb RIPC group were lower than those in the control group at 30 min, 6, 12, 24 and 48 h after operation (all P<0.05), and there was a significant difference in TNF-α level between the groups (P<0.01).
|Study Start Date:||February 2011|
|Study Completion Date:||June 2013|
|Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
Adult patients undergoing elective pulmonary lobectomy were received a remote ischemic preconditioning group after induction of anaesthesia.
Procedure: remote ischemic preconditioning
Remote ischaemic preconditioning consisted of three 5-min cycles of right upper limb ischaemia, induced by an automated cuff-inflator placed on the upper arm and inflated to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated.
Other Name: RIP
No Intervention: conventional
Adult patients undergoing pulmonary lobectomy were received no treatment after induction of anaesthesia.
Remote ischemic preconditioning is an intervention in which brief ischemia of one tissue or organ protects remote organs from a sustained episode of ischemia. It is known that one-lung ventilation in patients undergoing pulmonary resection, which may cause acute lung injury. The investigators did a single-blinded randomised controlled study to establish whether remote ischemic preconditioning reduces lung injury in these patients.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01307085
|Departmeng of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University|
|GuangZhou, Guangdong, China, 510080|
|Principal Investigator:||Xuan Ke Liu, Ph.d||Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University|