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Relationship Between Obstructive Sleep Apnea and Coronary Atherosclerosis (IDEAS-OSA)

This study has been completed.
Information provided by (Responsible Party):
Chi-Hang Lee, National University, Singapore Identifier:
First received: March 1, 2011
Last updated: January 7, 2014
Last verified: January 2014
Obstructive sleep apnea (OSA) is a respiratory disorder of sleep characterized by recurrent episodes of complete or partial upper airway obstruction, leading to intermittent oxygen deprivation. This results in sympathetic activation and surges in blood pressure, production of vasoactive substances, as well as activation of the inflammatory and procoagulant pathways. Epidemiological evidence indicates the prevalence of OSA is higher in patients with coronary artery disease than in the general population. The investigators recently showed that 65.7% and 41.9% of the Singapore patients admitted with myocardial infarction were found to have previously undiagnosed OSA and severe OSA, respectively. In a 10-year follow-up epidemiological study, OSA was independently associated with a higher prevalence of fatal and non-fatal cardiovascular events among the otherwise healthy general population. The investigators further showed that in patients who have undergone primary percutaneous coronary intervention for acute myocardial infarction, OSA was an independent predictor of future adverse event rates. Despite the observed association between OSA and adverse cardiovascular outcomes, the underlying pathophysiological mechanisms remain unclear. In this proposal, the investigators aim to elucidate the relationship between OSA and composition of coronary atherosclerotic plaques.

Coronary Artery Disease
Obstructive Sleep Apnea

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Intravascular Ultrasound Diagnostic Evaluation of Atherosclerosis in Singapore- Obstructive Sleep Apnea (IDEAS-OSA) Study

Resource links provided by NLM:

Further study details as provided by National University, Singapore:

Primary Outcome Measures:
  • Total Atheroma Volume [ Time Frame: Baseline ]
    Relationship between OSA and Total Atheroma Volume determined (IVUS) will be determined

Secondary Outcome Measures:
  • Thin-cap fibroatheroma [ Time Frame: Baseline ]
    Relation between OSA and prevalence of thin-cap fibroatheroma (VH-IVUS) will be determined

Enrollment: 118
Study Start Date: February 2011
Study Completion Date: March 2013
Primary Completion Date: January 2013 (Final data collection date for primary outcome measure)
Moderate to Severe OSA


Ages Eligible for Study:   21 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients aged 21 to 80 years who are scheduled to undergo either an elective, urgent or emergent diagnostic coronary angiography are eligible

Inclusion Criteria:

  • Angiogrqaphically documented coronary artery disease
  • De novo lesion
  • Native coronary artery

Exclusion Criteria:

  • known OSA
  • intubation and mechanical ventilation
  • electrical instability with a high risk of malignant ventricular arrhythmia
  • cardiogenic shock
  • previous coronary artery bypass surgery
  • chronic renal failure on dialysis
  • inability to give informed consent
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Please refer to this study by its identifier: NCT01306526

National University Health System
Singapore, Singapore, 119074
Sponsors and Collaborators
National University, Singapore
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Chi-Hang Lee, Associate Professor, National University, Singapore Identifier: NCT01306526     History of Changes
Other Study ID Numbers: DSRB: C/10/341
Study First Received: March 1, 2011
Last Updated: January 7, 2014

Keywords provided by National University, Singapore:
Thin-cap fibroatheroma
Vulnerable plaque
Coronary artery disease
Obstructive sleep apnea
Intravascular Ultrasound

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases processed this record on April 25, 2017