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Branched-chain Amino Acids Supplementation and Resistance Exercise-induced Muscle Damage and Inflammation

This study has suspended participant recruitment.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01305018
First Posted: February 28, 2011
Last Update Posted: May 5, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Sao Paulo
  Purpose
This study aims to evaluate the effects of branched-chain amino acids (BCAA) supplementation on resistance exercise-induced muscle damage and inflammation.

Condition Intervention
Muscle Damage Inflammation Dietary Supplement: BCAA Dietary Supplement: Leucine Dietary Supplement: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Effects of Leucine and Branched-chain Amino Acids (BCAA) Supplementation on Resistance Exercise-induced Muscle Damage and Inflammation: a Randomized, Double-blind, and Placebo-controlled Study

Resource links provided by NLM:


Further study details as provided by University of Sao Paulo:

Primary Outcome Measures:
  • Muscle maximal strength [ Time Frame: 4 days ]
  • Muscle edema [ Time Frame: 4 days ]
  • Muscle soreness [ Time Frame: 4 days ]

Secondary Outcome Measures:
  • Muscle inflammation [ Time Frame: 4 days ]
    Immunohistochemistry, protein expression.

  • Muscle damage [ Time Frame: 4 days ]
    Serum creatine kinase


Estimated Enrollment: 30
Study Start Date: August 2011
Estimated Study Completion Date: August 2012
Estimated Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise and BCAA Dietary Supplement: BCAA
7 g of leucine + 3,5 g of isoleucine + 3,5 g of valine per day during 9 days
Experimental: Exercise and Leucine Dietary Supplement: Leucine
7 g of leucine + 7 g of alanine per day during 9 days
Placebo Comparator: Exercise and Placebo Dietary Supplement: Placebo
14 g of alanine per day during 9 days

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Sedentary;
  • No muscle disorders;
  • Must be able to swallow tablets
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01305018


Locations
Brazil
University of São Paulo - School of Physical Education and Sports
São Paulo, Brazil, 05508-030
Sponsors and Collaborators
University of Sao Paulo
  More Information

Responsible Party: Claudia Ribeiro da Luz, University of São Paulo
ClinicalTrials.gov Identifier: NCT01305018     History of Changes
Other Study ID Numbers: 071287
First Submitted: February 25, 2011
First Posted: February 28, 2011
Last Update Posted: May 5, 2011
Last Verified: April 2011

Keywords provided by University of Sao Paulo:
Branched-chain amino acids
Leucine
Muscle damage
Inflammation
supplementation
resistance exercise-induced

Additional relevant MeSH terms:
Inflammation
Pathologic Processes