Orientation Agnosia: Clinical and Anatomical Study (AGNORIENT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01304576
Recruitment Status : Completed
First Posted : February 25, 2011
Last Update Posted : September 3, 2014
Information provided by (Responsible Party):
University Hospital, Rouen

Brief Summary:
The area of the brain responsible of visuospatial processing data and more specifically the orientation of an object or image is located in parietal lobe, especially on the right side. A dysfunction of this region would result in a disorder of recognition of the orientation of objects and images that the investigators call orientation agnosia. Several isolated cases are reported in the literature but to the investigators knowledge deficit has never been systematically searched, or put into perspective compared to other neuropsychological deficits. Moreover, the precise location of the lesion responsible for such a disorder remains uncertain. The objectives of this study are (1) detect the existence of orientation agnosia in case of right parietal lesion, and (2) to improve the understanding of such a deficit allowing better management of this disorder.

Condition or disease Intervention/treatment
Cerebrovascular Disorders Brain Lesions Behavioral: Neuropsychological testing Other: MRI

Detailed Description:

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 34 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Screening
Official Title: Orientation Agnosia: Neuropsychological Evaluation, Associated Symptoms, Clinical and Anatomical Correlations
Study Start Date : September 2010
Primary Completion Date : December 2013
Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: patient with right parietal lesions Behavioral: Neuropsychological testing
Experimental test about orientation agnosia and standard neuropsychological tests.
Other: MRI
Cerebral MRI
Active Comparator: patient with left parietal lesions Behavioral: Neuropsychological testing
Experimental test about orientation agnosia and standard neuropsychological tests.
Other: MRI
Cerebral MRI

Primary Outcome Measures :
  1. orientation agnosia evaluation [ Time Frame: 1 week to 6 months (average) ]
    orientation agnosia test

Secondary Outcome Measures :
  1. associated clinical symptoms especially apraxia [ Time Frame: 1 week to 6 months (average) ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age between 18 and 80 years
  • french language
  • right parietal lesion on cerebral imaging (CT-scan is sufficient), including stroke,arterial malformation, isolated tumoral lesion
  • informed consent

Exclusion Criteria:

  • previous neurological history except non complicated migraine and stabilized epilepsia without seizure since 5 years
  • previous psychiatric history except depression without hospitalization > one week or anxiety with maximum one anxiolytic treatment
  • drug or alcohol abuse
  • severe cranial traumatism
  • other severe chronic pathology
  • psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month
  • visual impairment
  • motor or sensory deficit sufficient to render impossible neuropsychological tests
  • patient without judicial or administrative liberty
  • measure of legal protection or no capable to express their consent
  • pregnancy or breastfeeding

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01304576

CHU de Rouen - Hôpitaux de Rouen
Rouen, Haute-Normandie, France, 76031
Sponsors and Collaborators
University Hospital, Rouen
Principal Investigator: Olivier MARTINAUD, Doctor Service de neurologie et centre mémoire de ressources et recherche

Responsible Party: University Hospital, Rouen Identifier: NCT01304576     History of Changes
Other Study ID Numbers: 2009/126/HP
number ID RCB 2009-A01005-52 ( Other Identifier: Afssaps )
First Posted: February 25, 2011    Key Record Dates
Last Update Posted: September 3, 2014
Last Verified: September 2014

Keywords provided by University Hospital, Rouen:
parietal lesions

Additional relevant MeSH terms:
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Perceptual Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms