Does Glaucoma Cause Loss of Brain Function?
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01303939|
Recruitment Status : Completed
First Posted : February 25, 2011
Last Update Posted : June 11, 2015
|Condition or disease|
Death of retinal ganglion cells causes loss of neurons in areas other than just the visual cortex. These neurodegenerative changes decrease the patient's ability to perform the activities of daily living. Tensor-based morphometry analysis of MRI brain scans will reveal areas of cortical degeneration in glaucoma patients, and the extent of damage in these areas will correlate with their ability to perform vision-dependent tasks, as measured by the Assessment of Ability Related to Vision (AARV).
Patients with glaucoma who were outliers in Assessment of Ability Related to Vision (AARV) Study or Assessment of Disability related to vision (ADREV) Study, in that they have poor performance-based measure scores despite having midrange visual field scores.
Mini-Mental State Exam and T-1 weighted MRI brain scan and will be performed.
|Study Type :||Observational|
|Actual Enrollment :||37 participants|
|Official Title:||Neuroimaging Brain Changes in Glaucoma|
|Study Start Date :||August 2010|
|Actual Primary Completion Date :||March 2012|
|Actual Study Completion Date :||March 2012|
Patients who were outliers from the AARV or ADREV Studies.
Age, gender and race matched group of healthy individuals with no ocular diseases.
- Brain atrophy [ Time Frame: 2 days ]Mini-Mental State Exam and T-1 weighted MRI brain scan and will be performed
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01303939
|United States, Pennsylvania|
|Wills Eye Institute, Glaucoma Service|
|Philadelphia, Pennsylvania, United States, 19107|
|Principal Investigator:||George L Spaeth, MD||Glaucoma Service, Wills Eye Institute|