The Effects of Normobaric Hypoxia on Blood Glucose Levels.
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The purpose of this research study is to observe whether there is a change in blood glucose levels in response to a 2 hour oral glucose tolerance tests (OGTT) during acute normobaric hypoxia (short term low oxygen levels at normal ambient air pressure).
Change in glucose levels at altitude [ Time Frame: 1 year ]
Subjects will be placed on a Reduced Oxygen Breathing Device (ROBD2) to simulate 3 different altitudes at three separate and distinct time periods (ground, 8,000 feet and 12,000 feet) then obtain c-peptide and 2-hour OGTT to determine blood glucose changes during acute normobaric hypoxia.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
We are recruiting male and female patients (MOFH personnel and DoD beneficiaries) whom are at least 18 years of age from the Nellis Air Force Base population.
Inclusion Criteria (non-diabetics):
Tricare Insurance Beneficiary (military insurance) receiving care at Nellis AFB
5 males with a BMI < 25; 5 males with a BMI > 25 at least 18 years of age (MOFH personnel and DoD beneficiaries).
5 females with a BMI < 25; 5 females with a BMI > 25 at least 18 years of age (MOFH personnel and DoD beneficiaries).
Exclusion Criteria (non-diabetics):
History of abnormal fasting glucose.
Any medications that change glucose control to include systemic steroid and diabetic medications.
History of claustrophobia.
Pregnant or breast feeding.
Physical inability to wear/use the ROBD2
Inclusion Criteria (diabetics):
-5 males and/or females, at least 18 years of age, that are type 2 diabetics (MOFH personnel and DoD beneficiaries).