Smoking-induced Dopamine Release: a [11C]-(+)-PHNO PET Study in Humans
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|ClinicalTrials.gov Identifier: NCT01302262|
Recruitment Status : Completed
First Posted : February 24, 2011
Last Update Posted : March 5, 2013
|Condition or disease|
|Tobacco Use Disorder|
|Study Type :||Observational|
|Actual Enrollment :||10 participants|
|Official Title:||Does the Insula Control Smoking-induced Dopamine Release? A TMS/[11C]-PHNO Study in Humans. Part I: Smoking-induced Dopamine Release: a [11C]-(+)-PHNO PET Study in Humans.|
|Study Start Date :||February 2011|
|Actual Primary Completion Date :||February 2013|
|Actual Study Completion Date :||March 2013|
Healthy male and female smokers. Each subject will undergo PET scan (along with craving and anxiety questionnaires) on two conditions - Smoking and Non-smoking - on two separate visits.
- [11C]-(+)-PHNO binding potential [ Time Frame: Up to 14 days between PET scans ]The process of imaging requires the injection of a positron-emitting radiotracer (here, [11C]-(+)-PHNO) that binds to the protein of interest (here, dopamine receptor DRD2/3) followed by the measurement of this binding using the PET scanner. Dopamine release increases DRD 2/3 occcupancy which results in decreased radiotracer's binding potential, and vice versa. [11C]-(+)-PHNO binding potential will be measured on two different conditions (Smoking vs. Non-smoking) on two separate days.
- Subjective reports of craving [ Time Frame: Up to 14 days between PET scans ]Levels of subjective craving will be assessed prior to and after each condition (Smoking vs. Non-smoking) on two separate days. Minnesota Nicotine Withdrawal Scale, Tiffany Questionnaire of Smoking Urges, The Urge to Smoke scale, Tobacco Craving Questionnaire, and 21-item Visual Analogue Scale will be used.
- Subjective reports of anxiety [ Time Frame: Up to 14 days between PET scans ]Subjective reports of anxiety will be collected prior to and after each condition (Smoking vs. Non-smoking) on two separate days. State anxiety questions from the Spielberg State-Trait Anxiety Inventory will be used.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01302262
|Centre for Addiction and Mental Health - 33 Russell St|
|Toronto, Ontario, Canada, M5S 2S1|
|Principal Investigator:||Bernard Le Foll, MD||Centre for Addiction and Mental Health|