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The Effect of Chlorella on Glycemic Control of Diabetes

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2011 by Cardinal Tien Hospital.
Recruitment status was:  Recruiting
Tri-Service General Hospital
Information provided by:
Cardinal Tien Hospital Identifier:
First received: February 22, 2011
Last updated: NA
Last verified: February 2011
History: No changes posted
Chlorella, a type of unicellular fresh water algae, has been a popular foodstuff in Asia, especially in Taiwan. Recent studies have shown the hypoglycemic effects of Chlorella through increasing glucose uptake in the liver and muscle, lowering serum free fatty acid levels, or activation of PPAR gamma receptor. However, the hypoglycemic effect in diabetic patients have not been studied. In order to clarify the hypoglycemic effects and mechanism of Chlorella in diabetic patients, the investigators conducted a 12-week randomized, double-blind, placebo-control trial on diabetic patients.

Condition Intervention
Diabetes Drug: Chlorella

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator)
Primary Purpose: Treatment

Further study details as provided by Cardinal Tien Hospital:

Primary Outcome Measures:
  • HbA1c [ Time Frame: 12 weeks ]

Secondary Outcome Measures:
  • Insulin concentration during oral glucose tolerance test [ Time Frame: 12 weeks ]
    All subjects received the first oral glucose tolerance test before intervention(week 0), and the second oral glucose tolerance test on week 12.

Estimated Enrollment: 30
Study Start Date: January 2010
Arms Assigned Interventions
Experimental: Chlorella Drug: Chlorella


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 18-70 years old
  • type 2 diabetes with less than 2 kinds of oral antidiabetes drugs
  • Hba1c: 7.0-9.0

Exclusion Criteria:

  • type 1 diabetes
  • pregnancy
  • acute infectious disease
  • autoimmune disease
  • hemodynamic unstable
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01301287

Contact: Fone-Ching Hsiao, MD

Cardinal Tien Hospital Recruiting
New Taipei City, Taiwan, 23137
Contact: Fone-Ching Hsiao, MD   
Sponsors and Collaborators
Cardinal Tien Hospital
Tri-Service General Hospital
Principal Investigator: Dee Pei, MD Cardinal Tien Hospital 362, Chung Cheng Rd., Hsintien Taipei County 23137 Taiwan R.O.C.
  More Information Identifier: NCT01301287     History of Changes
Other Study ID Numbers: CTH-96-2-028
Study First Received: February 22, 2011
Last Updated: February 22, 2011 processed this record on July 21, 2017