Defining 31Phosphorous Magnetic Resonance Spectroscopy Characteristics in Patients With Mitochondrial Myopathy
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ClinicalTrials.gov Identifier: NCT01301235
Recruitment Status :
First Posted : February 23, 2011
Last Update Posted : April 30, 2012
Massachusetts General Hospital
Information provided by (Responsible Party):
Amy Fleischman, MD, Massachusetts General Hospital
This is a developmental protocol to determine the MRI based 31P-MRS changes seen in subjects with mitochondrial myopathy using our dynamic exercise protocol and to identify the ideal variable(s) to represent mitochondrial function.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Adults with mitochondrial disease
Men and women ≥ age 18 years old with primary mitochondrial myopathy
Known alteration in electron transport chain activity (<25 % activity of ETC) or known mutations in mitochondrial gene.
Failure based on standard clinical MRI Screening form - the form is intended to establish the safety of subjects participating in the MRI scan without divulging any confidentiality information -