Effect of an Anti-inflammatory on Tooth Sensitivity Caused by Bleaching.
Perhaps the use of a more selective anti-inflammatory drug, capable of inhibiting enzyme specific for pain may be more effective in preventing the tooth sensitivity caused by the inflammatory response produced by in-office bleaching. To the extent of the authors´ knowledge, no study has so far addressed the use of a selective anti-inflammatory drug specific for pain enzyme on tooth sensitivity, being this the aim of the present investigation.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:||Effect of Preoperative Use of an Anti-inflammatory on Tooth Sensitivity Caused by In-office Bleaching: a Randomized, Double-blind Clinical Trial.|
- Sensibility [ Time Frame: Evaluation of sensibility during the tooth whitening and 24/48 after of the bleaching ] [ Designated as safety issue: No ]The effect of the product will be evaluated immediately, 1 Hour, 24 and 48 hours after the teeth bleaching applied to the patients, using a verbal scale of 5 points, also a numerical scale of 101 points will be used, In addition to these two scales a Visual Analogue Scale (VAS, which consists of 10 cm line. One of the extremes presents a "no pain" indication and the other "unbearable pain". Each patient will be directed to mark with a single vertical dash the point that better matches his pain rating at the moment of the evaluation.
- Colour [ Time Frame: In the first session and second session of the tooth whitening ] [ Designated as safety issue: No ]For a color rating before, immediately and 30 days after the bleaching treatment the spectrophotometer Vita Easy Shade will be used together with the Vita Classica scale, which will be organized from the highest value (B1) to the lowest (C4). To evaluate color with the spectrophotometer, first a mold will be made of the upper anterior teeth from canine to canine with heavy condensation silicone, which will serve as a guide to the spectrophotometer. A Window of 3 mm in diameter will be made on the vestibular face of the silicon guide in the area of the tooth where the color will be assessed.
|Study Start Date:||April 2010|
|Estimated Study Completion Date:||November 2011|
|Estimated Primary Completion Date:||November 2011 (Final data collection date for primary outcome measure)|
To determine the effect pre operative of anti-inflammatory eotricoxib in the reduction of tooth sensitivity caused by in-office bleaching of vital teeth using hydrogen peroxide 35% and verify effectiveness of color change caused by that product.
Group 1 - Control Group will receive two doses of placebo tablet administered a every 8 hours, Group 2 - experimental Etoricoxib will receive two doses of selective anti-inflammatory to enzyme cyclooxygenase 2 (COX-2) (Etoricoxib 60 mg) given once every 24 hours;
Other Name: Anti-inflamatory
Please refer to this study by its ClinicalTrials.gov identifier: NCT01300780
|Universidade Estadual de Ponta Grossa|
|Guarapuava, Paraná, Brazil, 84030900|
|Principal Investigator:||Alessandra Reis, doctor||Universidade Estadual de Ponta Grossa|