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Oral Antibiotic Treatment of Helicobacter Pylori Reduces Intestinal Colonization Rates With Oxalobacter Formigenes

This study has been completed.
Information provided by:
VA New York Harbor Healthcare System Identifier:
First received: February 18, 2011
Last updated: NA
Last verified: February 2011
History: No changes posted
The investigators are finding out if giving antibiotics for Helicobacter pylori will eliminate colonization of the colon by Oxalobacter formigenes.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Oral Antibiotic Treatment of Helicobacter Pylori Reduces Intestinal Colonization Rates With Oxalobacter Formigenes

Resource links provided by NLM:

Further study details as provided by VA New York Harbor Healthcare System:

Enrollment: 50
Study Start Date: January 2003
Study Completion Date: June 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
Antibiotics for H. pylori
Patients who underwent upper endoscopy and were found to have H. pylori, and were then to be treated with antibiotics for eradication of H. pylori
Control group, no H. pylori
Patients who underwent upper endoscopy and found to not have H. pylori, and then would not receive antibiotics

Detailed Description:

Background and objectives: Oxalobacter formigenes (OF) may play a protective role in preventing calcium oxalate stones. Intestinal colonization by OF is associated with reduced urinary oxalate excretion. Exposure to antibiotics may be an important factor contributing to variable rates of colonization. This is the first prospective study to evaluate the effect of antibiotics on OF colonization.

Design, setting, participants, & measurements: The effect of antibiotics on OF colonization was compared in 2 groups: a group receiving antibiotics for gastric infection with Helicobacter pylori (HP) and a group without HP that not receiving antibiotics. OF colonization in stool was detected by oxalate degradation at baseline and after 1 and 6 months.


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing upper endoscopy for any indication and who would have determination of presence or absence of H. pylori. Stool samples then positive for colonization with Oxalobacter formigenes.

Inclusion Criteria:

  • age 18-80 years old
  • undergoing upper endoscopy
  • H. pylori present or absent on gastric histology
  • stool positive for Oxalobacter formigenes

Exclusion Criteria:

  • unable to consent
  • stool negative for Oxalobacter formigenes
  Contacts and Locations
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Please refer to this study by its identifier: NCT01300039

Sponsors and Collaborators
VA New York Harbor Healthcare System
Principal Investigator: David S Goldfarb, MD New York Harbor VA Medical Center
  More Information

Responsible Party: David S Goldfarb MD, New York Harbor VA Medical Center Identifier: NCT01300039     History of Changes
Other Study ID Numbers: 573
Study First Received: February 18, 2011
Last Updated: February 18, 2011

Keywords provided by VA New York Harbor Healthcare System:
Helicobacter pylori

Additional relevant MeSH terms:
Kidney Calculi
Kidney Diseases
Urologic Diseases
Urinary Calculi
Pathological Conditions, Anatomical
Anti-Bacterial Agents
Antibiotics, Antitubercular
Anti-Infective Agents
Antitubercular Agents processed this record on April 28, 2017