Sonographic Measurement of Bladder Wall Thickness in Patients With Neurogenic Bladder Dysfunction
Video-urodynamic investigations are regarded as the current standard diagnostics for neurogenic bladder dysfunction in patients with spinal cord injury. This examination is exact, but time consuming, costly and associated with the risk of urinary tract infection.
In patients with lower urinary tract symptoms due to benign prostate hyperplasia, sonographic measurement of bladder wall thickness has been demonstrated to be able to replace urodynamic testing for the diagnosis of infravesical obstruction.
Hypothesis: measurement of bladder wall thickness in patients with neurogenic bladder dysfunction due to spinal cord injury is closely related to the known risk factors for upper urinary tract deterioration (bladder compliance, detrusor leak point pressure) in this group of patients and can therefore replace urodynamic examination in selected cases.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||Sonographic Measurement of Bladder Wall Thickness in Patients With Neurogenic Bladder Dysfunction Due to Spinal Cord Injury|
- correlation bladder wall thickness and detrusor compliance [ Time Frame: calculated from maximum bladder filling ] [ Designated as safety issue: No ]measurement of detrusor compliance at maximum bladder volume; measurement of bladder wall thickness at maximum bladder volume
- correlation bladder wall thickness and maximum detrusor pressure [ Time Frame: measurement at maximum bladder capacity ] [ Designated as safety issue: No ]correlation between bladder wall thickness and maximum detrusor pressure during the urodynamic storage phase
|Study Start Date:||August 2009|
|Study Completion Date:||October 2011|
|Primary Completion Date:||October 2011 (Final data collection date for primary outcome measure)|
No Intervention: one arm; neurogenic bladder dysfunction
evaluation of the clinical utility of bladder wall thickness as a diagnostic tool in patients with spinal cord injury
Other: sonographic measurement of bladder wall thickness
measurement of bladder wall thickness by ultrasound at different filling states of the bladder during urodynamic investigation
Please refer to this study by its ClinicalTrials.gov identifier: NCT01299792
|Swiss paraplecic centre|
|Nottwil, Switzerland, 6007|
|Principal Investigator:||Juergen Pannek, MD||Swiss Paraplegic Centre|