MEG and DTI of Neural Function and Connectivity in Traumatic Brain Injury (Dana-REAC)
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|ClinicalTrials.gov Identifier: NCT01298557|
Recruitment Status : Completed
First Posted : February 17, 2011
Last Update Posted : May 1, 2013
|Condition or disease|
|Traumatic Brain Injury Post-concussive Symptoms|
|Study Type :||Observational|
|Actual Enrollment :||69 participants|
|Observational Model:||Case Control|
|Official Title:||Magnetoencephalography and High-Field Diffusion Tensor Magnetic Resonance Imaging of Neural Function and Connectivity in Traumatic Brain Injury|
|Study Start Date :||February 2007|
|Primary Completion Date :||February 2013|
|Study Completion Date :||February 2013|
Traumatic brain injured patients
This group consists of participants who suffered a traumatic brain injury an average of 4 months to 4 years prior to testing. Patients must not have history of prior head injury, substance abuse, psychiatric illness, or contraindications to MRI.
Controls (no traumatic brain injury)
This group consists of participants who do not have a history of brain trauma. Furthermore, controls must not suffer from substance abuse, psychiatric illness, or have contraindications to the MRI.
- Changes in white matter tract structure [ Time Frame: up to 4 years following date of injury ]We believe that brain injury results in selective disruption of the associative white matter tracts of the cerebral hemispheres, with resulting functional impairment of the network of cortical regions that are interconnected by these long-range association pathways. We propose that traumatic white matter injury can be measured with diffusion tensor imaging (DTI). We evaluate DTI using 3T and 7T MRI. Participants receive scans at only one time-point.
- Neurocognitive function [ Time Frame: up to 4 years following date of injury ]We hope to better understand the long-term cognitive and behavioral sequelae of traumatic brain injury (TBI) by correlating neurocognitive testing data with imaging data. We will also compare neurocognitive testing data between patients and controls to help illustrate the impact of brain trauma on these neurocognitive symptoms. Our participants receive testing at only one time-point.
- Cortical activation [ Time Frame: up to 4 years following date of injury ]We believe that brain injury results in selective disruption of the associative white matter tracts of the cerebral hemispheres, with resulting functional impairment of the network of cortical regions that are interconnected by these long-range association pathways. We propose that impaired cortical activation can be detected with magnetoencephalography (MEG). We will compare patients' data with data of controls. Our participants are scanned at only one time-point.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01298557
|United States, California|
|San Francisco General Hospital|
|San Francisco, California, United States, 94110|
|Principal Investigator:||Pratik Mukherjee, MD, PhD||UCSF Department of Radiology and Bioengineering|