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Leptin Signaling in Lean and Obese Humans (Leptin signali)

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ClinicalTrials.gov Identifier: NCT01297426
Recruitment Status : Withdrawn (funding expired)
First Posted : February 16, 2011
Last Update Posted : December 24, 2015
Sponsor:
Information provided by (Responsible Party):
VA Office of Research and Development

Study Description
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
Brief Summary:
Obesity does not respond to high circulating levels of the hormone leptin. This study is aiming at finding out why this happens and open new avenues for treatment of obesity.

Condition or disease
Obesity

Detailed Description:
Ex vivo and in vitro identification and study of leptin signaling pathways in commercially available cell lines serum/ plasma samples and discarded tissues from humans.

Study Design
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Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Leptin Signaling in Humans
Study Start Date : April 2011
Actual Primary Completion Date : June 2015
Actual Study Completion Date : June 2015
Groups and Cohorts
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Group/Cohort
Group 1
Lean and obese, diabetic and non diabetics


Outcome Measures
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :
  1. Westerns / activation of signaling pathways (uo to two hours after treatment) [ Time Frame: 04/01/2016 ]

Eligibility Criteria
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
diabetic or nondiabetic lean and obese subjects
Criteria

Inclusion Criteria:

  • men and women
  • ages 18 to 65
  • BMI ranges between 20 and 45 kg/m2

Exclusion Criteria:

  • subjects requiring special diets
  • history of illness other than obesity of diabetes
  • taking medications known to influence glucose metabolism
  • subjects with history of anaphylactic reaction or hypersensitivity to e. coli derived proteins or anesthetic agents
  • women who are breastfeeding, pregnant or wanting to become pregnant
  • subjects with bleeding dyscrasia or poor wound healing
Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01297426


Locations
United States, Massachusetts
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States, 02130
Sponsors and Collaborators
VA Office of Research and Development
Investigators
Principal Investigator: Christos Mantzoros, MD DSc VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party: VA Office of Research and Development
ClinicalTrials.gov Identifier: NCT01297426     History of Changes
Other Study ID Numbers: ENDA-013-10F
First Posted: February 16, 2011    Key Record Dates
Last Update Posted: December 24, 2015
Last Verified: December 2015