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Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?

This study has been terminated.
(Failure to recruit participants)
Rigshospitalet, Denmark
Information provided by (Responsible Party):
Copenhagen University Hospital at Herlev Identifier:
First received: February 14, 2011
Last updated: May 23, 2013
Last verified: February 2012
The purpose of this study is to determine if the pre-operative levels of sex-hormones can be used to identify the varicocele patients who can expect improvements in their semen parameters following varicocelectomy.

Condition Intervention
Semen Quality
Procedure: Hormone and semen measurements before varicocelectomy

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?

Resource links provided by NLM:

Further study details as provided by Copenhagen University Hospital at Herlev:

Primary Outcome Measures:
  • Change in semen parameters [ Time Frame: February 2017 (anticipated duration of the study) ]

Secondary Outcome Measures:
  • Change in hormone levels [ Time Frame: February 2017 (anticipated end of the study) ]

Enrollment: 3
Study Start Date: February 2011
Estimated Study Completion Date: February 2017
Estimated Primary Completion Date: February 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Hormone/semen measurements before and after varicocelectomy
We will measure sex-hormone and semen quality in patients both before and after varicocelectomy. The purpose is to asses if preoperative hormone levels are predictive for who will have improved semen quality after surgery.
Procedure: Hormone and semen measurements before varicocelectomy
Before surgery we will measure sex-hormone levels and semen parameters. This will be repeated after the varicocelectomy to record any changes.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Varicocele (grade 1-3) and surgery planned for this condition
  • At least 18 years of age

Exclusion Criteria:

  • Fever within 3 months before the first semen sample
  • Malformations of the uro-genital tract
  • Karyotype other than 46, XY or Y micro deletions
  • Endocrine disease
  • Chronic disease
  • Medications which reduce semen quality
  • Epididymitis within 6 months before surgery
  Contacts and Locations
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Please refer to this study by its identifier: NCT01296230

University Department of Growth and Reproduction GR, Section 5064, Rigshospitalet
Copenhagen, Denmark, 2100
Department of Urology, Herlev Hospital
Herlev, Denmark, 2730
Sponsors and Collaborators
Copenhagen University Hospital at Herlev
Rigshospitalet, Denmark
  More Information

Responsible Party: Copenhagen University Hospital at Herlev Identifier: NCT01296230     History of Changes
Other Study ID Numbers: H-2-2010-067
Study First Received: February 14, 2011
Last Updated: May 23, 2013

Additional relevant MeSH terms:
Genital Diseases, Male
Genital Diseases, Female
Vascular Diseases
Cardiovascular Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs processed this record on May 22, 2017