Interaction Effect of Asthma and Aeroallergen Category on the Psychological Status in Allergic Rhinitis Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01295255
Recruitment Status : Completed
First Posted : February 14, 2011
Last Update Posted : February 14, 2011
Information provided by:
Beijing Tongren Hospital

Brief Summary:
Allergic rhinitis (AR) and asthma are considered as "one airway, one disease". Although there is increasing evidence for an association between allergy and depression, it remains unknown if the relationship between AR and asthma has extra influence on the psychological status of the patients. The aim of our study was to investigate the influence pattern of asthma on the psychological status in AR patients. The Symptom Checklist-90 (SCL-90) was employed to analyze the psychological status of 524 individuals with AR. Independent sample T-tests, one-way ANOVA and multivariate ANOVA were used for data analyses.

Condition or disease
Hypersensitivity Psychologic Factors in Physical Conditions Classified Elsewhere Respiratory Tract Diseases Allergic Rhinitis

Study Type : Observational
Actual Enrollment : 524 participants
Observational Model: Cohort
Study Start Date : February 2009
Actual Primary Completion Date : October 2009
Actual Study Completion Date : November 2009

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MedlinePlus related topics: Asthma

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Ages Eligible for Study:   16 Years to 60 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
524 affected individuals (311 males and 213 females) with AR were prospectively recruited from the rhinology clinic of the Otolaryngology, Head and Neck Surgery Department of Beijing Tongren Hospital from February 2009 to November 2009.

Inclusion Criteria:

  • Patients suffered from rhinitis symptoms such as nasal itching, sneezing, nasal obstruction and running nose, all patients had not undergone any medicine therapy in the past one week; nasal endoscopy showed a pale and edematous nasal mucosa, nasal discharge and swollen inferior turbinates. Every nasal symptom was scored on Visual analog scale (VAS, 0-3 score) respectively. A score of 0 indicated no nasal symptom, 1 indicated slight nasal symptoms, 2 indicated obvious nasal symptom, but which could still be endured, and 3 indicated obvious nasal symptoms that could not be endured;
  • Age between 16 to 60 years;
  • A positive skin prick test (SPT)to at least one allergen, the level of response equal to or exceeding ++. The following inhalant allergens were tested: Der p; Der f; Animal hair; Trees; Grasses; Cereals; Mugwort; Dandelion; Giant ragweed; Chenopodium album; Humulus; Locust; Blatella germanica; Pine; Plantain; Curvularia lunata; Candida albicans; Penicillium notatum; Alternaria tenuis and Aspergillus fumigatu. The reactions were evaluated based on the mean wheal diameter at 15 minutes after application of the extracts. The mean diameters of each allergen wheals were calculated from the sum of the largest measurement across the wheal and the largest wheal measurement perpendicular to this divided by two. In addition, we calculated the skin index (SI) as the ratio of allergen weal diameter divided by the histamine weal size. The SPT result for each allergen was defined in terms of the SI value as follows: +: SI≤0.5; ++: 0.5<SI≤1.0; +++: 1.0<SI≤2.0; ++++: SI>2.0.

Exclusion Criteria:

  • AR combined with hypertension, diabetes or other chronic diseases;
  • AR combined with tumor in the nasal cavity;
  • AR combined with eczema;
  • Acute infection in the past one week;
  • Failure to complete the questionnaires;
  • AR patients undergoing negative life events.

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01295255

Sponsors and Collaborators
Beijing Tongren Hospital
Principal Investigator: DeMin Han, Phd Beijing Tongren Hospital

Responsible Party: Demin Han, Beijing Tongren Hospital Identifier: NCT01295255     History of Changes
Other Study ID Numbers: 1130
First Posted: February 14, 2011    Key Record Dates
Last Update Posted: February 14, 2011
Last Verified: January 2011

Keywords provided by Beijing Tongren Hospital:
Allergic rhinitis
Psychological status

Additional relevant MeSH terms:
Rhinitis, Allergic
Respiratory Tract Diseases
Nose Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases