Association of Circulating Chemerin Levels and Arterial Stiffness

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01293929
Recruitment Status : Unknown
Verified January 2011 by Korea University.
Recruitment status was:  Recruiting
First Posted : February 11, 2011
Last Update Posted : March 4, 2011
Information provided by:
Korea University

Brief Summary:
Chemerin is a novel adipokine that might provide a link between chronic inflammation and obesity. Pulse wave velocity(PWV) is a useful method for examining arterial stiffness, meaning early-stage atherosclerosis. Therefore, in the present study, the investigators examined the relationship between circulating chemerin and arterial stiffness measured using PWV in obese persons.

Condition or disease
Obesity Atherosclerosis

Study Type : Observational
Estimated Enrollment : 120 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Study Start Date : February 2011
Estimated Primary Completion Date : March 2011
Estimated Study Completion Date : March 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Atherosclerosis
U.S. FDA Resources

Non- obese group
Obese group

Primary Outcome Measures :
  1. The difference of serum chemerin level between obese and non-obese groups [ Time Frame: at the time of initial enrollment (4weeks) ]
    serum chemerin levels of all participants were by determined by an enzyme-linked immunosorbent assay (ELISA) kit (Biovender Laboratory Medicine Inc., Modrice, Czech Republic)

Secondary Outcome Measures :
  1. The correlation of serum chemerin levels with arterial stiffness [ Time Frame: at the time of enrollment (4 weeks) ]
    Arterial stiffness was measure using a Colin Waveform Analyser (model BP-203RPE II; Colin, Komaki, Japan). It was expressed as branchial ankle pulswe wave velocity (baPWV)

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Obese and age, gender matched non-obese group who underwent a medical health check in the Korea University Guro hospital

Inclusion Criteria:

  • Self referred persons for visiting routine medical check in our clinic

Exclusion Criteria:

  • Malignancy
  • Severe renal or hepatic disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01293929

Contact: Hye Jin Yoo 82226263045

Korea, Republic of
Hye Jin Yoo Recruiting
Seoul, Korea, Republic of
Contact: Hye Jin Yoo    82226263045   
Sponsors and Collaborators
Korea University

Responsible Party: Hye Jin Yoo, Korea university Identifier: NCT01293929     History of Changes
Other Study ID Numbers: A102065-1011-1070100
First Posted: February 11, 2011    Key Record Dates
Last Update Posted: March 4, 2011
Last Verified: January 2011

Additional relevant MeSH terms:
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases