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Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.
Condition or disease
Dry SocketWound Infection
Other: Colgate Total ToothpasteOther: Colgate Regular Toothpaste
This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 35 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
must include at least one mandibular third molar with partial or full bony impaction
no sign of active pericoronal (around the crown) infections
must have not taken antibiotics for any reason in the past 30 days
must be healthy and between 18 and 35 years of age
must be able to read and sign an informed consent
Subjects with systemic diseases and pregnant or lactating women
Subjects with advanced periodontal diseases or having two or more untreated caries lesions
Subjects who cannot read and sign an informed consent